Fast Troponin as a Biomarker to Assess Exercise-induced Muscle Damage in Muscle Diseases

Mads Peter Godtfeldt Stemmerik

Status: Completed

Conditions: Limb-Girdle Muscular Dystrophy Type 2; McArdle Disease; Becker Muscular Dystrophy

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT04349566

FAST TROPONIN

Details and patient eligibility

About

The purpose of the study is to explore the biomarker Fast Troponins response to exercise in patients with Becker muscular dystrophy, Limb-girdle muscular dystrophy and McArdle disease

Enrollment: 36 patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• The ability to cycle
• No concurrent medical condition that could interfere with interpretation of the results
• Molecular diagnosis of the specific condition in specified patient groups or healthy control
• No active muscle injury on the test day (caused by recent exercise, seizures, trauma, etc.)

Exclusion criteria

• Competing conditions at risk of compromising the results of the study
• Cardiac or pulmonary disease contraindicating peak exercise testing or strenuous exercise
• Veins that are too difficult to puncture for blood sampling, evaluated by the investigator
• Severe muscle weakness, that prevents the subject completing the exercise test, evaluated by the investigator