Fasted Exercise and LDL-C

University of Bath

Status: Completed

Conditions: Cardiovascular Diseases

Treatments: Other: Meal timing

Study type: Interventional

Funder types: Other

Identifiers

NCT05279014

EIRA1-7137

Details and patient eligibility

About

Cardiovascular disease (CVD) is the leading cause of death in the UK and worldwide with low density lipoprotein cholesterol (LDL-C) being one of the most important modifiable risk factors. Physical activity is inexpensive and research shows that it consistently improves high density lipoprotein and triglyceride concentrations. However, fails to improve LDL-C concentrations. Preliminary research suggests fasted exercise could potentially improve LDL-C concentrations. The majority of research in these areas have also mostly been done in males with the results generalised to females. As it is known that lipid metabolism and CVD risk is different between sexes it is possible that the response to fasted exercise may also be different between sexes. This aim of this study is to assess the effect of physical activity performed before or after a meal on plasma LDL-C concentrations in men and women and explore sex differences. The study will also assess the effect of fasted exercise on other CVD risk factors.

Enrollment: 29 patients

Sex: All

Ages: 25 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age 18-65 years
• Body mass index 20-40kg/m2
• Physically inactive (exercise for less than 150 minutes per week)

Exclusion criteria

• Weight instability (>5kg change in body mass over last 6 months)
• Diagnosis of diabetes or CVD
• Pregnant or lactating
• Any medical condition or medication that could introduce bias into the study (eg. lipid disorders, lipid or glucose metabolism altering medications eg statins)

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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29 participants in 2 patient groups

Exercise in a fed-state

Active Comparator group

Description:

12-weeks of exercise training, 50-minutes, 3 days per week performed 1.5-3 hours after a high-carbohydrate meal (1 g/kg body mass).

Treatment:

Other: Meal timing

Exercise in a fasted-state

Experimental group

Description:

12-weeks of exercise training, 50-minutes, 3 days per week performed after at least an 8-hour fast. A high-carbohydrate meal (1 g/kg body mass) will be consumed after exercise.

Treatment:

Other: Meal timing