Fasted Exercise in People With Type 1 Diabetes

Liverpool John Moores University

Status: Completed

Conditions: Type1diabetes

Treatments: Behavioral: Effects of the type of exercise on blood glucose concentrations

Study type: Interventional

Funder types: Other

Identifiers

NCT03544684

T1D_PARTA

Details and patient eligibility

About

This study aims to compare the effect of a bout of high-intensity interval training (HIT) with a bout of moderate-intensity continuous training (MICT) on glucose concentrations over the subsequent 24h period.

Full description

This study aims to compare the effect of a bout of high-intensity interval training (HIT) with a bout of moderate-intensity continuous training (MICT) on glucose concentrations over the subsequent 24h period. Fourteen people with type 1 diabetes (duration of type 1 diabetes 8.2±1.4 years), all on basal-bolus regimen, completed a randomised, counterbalanced, crossover study. Continuous glucose monitoring was used to assess glycaemic control following a single bout of HIT (6 x 1min intervals) and 30 mins of moderate-intensity continuous training (MICT) on separate days, compared to a non-exercise control day (CON). Exercise was undertaken following an overnight fast with omission of short-acting insulin. Capillary blood glucose samples were recorded pre and post-exercise to assess the acute changes in glycaemia during HIT and MICT.

Enrollment: 14 patients

Sex: All

Ages: 18 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• duration of type 1 diabetes >6 months
• basal bolus regimen
• no significant history of hyper- or hypoglycaemia (determined from medical history

Exclusion criteria

• duration of type 1 diabetes <6 months,
• insulin pump therapy
• significant history of hyper- or hypoglycaemia (determined from medical history)
• obesity (BMI >30 kg∙m-2)
• pregnancy or planning pregnancy, uncontrolled hypertension (>180/100 mmHg)
• angina
• autonomic neuropathy
• taking any medication that affects heart rate
• major surgery planned within 6 weeks of the study
• severe nonproliferative and
• unstable proliferative retinopathy

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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14 participants in 3 patient groups

Control day with no exercise

Experimental group

Description:

glycaemic profile will be assessed using continuous glucose monitors following a single 24-hour period in which participants performed no exercise

Treatment:

Behavioral: Effects of the type of exercise on blood glucose concentrations

High intensity interval training (HIT)

Experimental group

Description:

glycaemic profile will be assessed using continuous glucose monitors following a 24-hour period whereby participants performed a single bout of high-intensity interval training (HIT) in the morning under fasted conditions

Treatment:

Behavioral: Effects of the type of exercise on blood glucose concentrations

moderate intensity continuous training (MICT)

Experimental group

Description:

glycaemic profile will be assessed using continuous glucose monitors following a 24-hour period whereby participants performed a single bout of moderate-intensity continuous training (MICT) in the morning under fasted conditions

Treatment:

Behavioral: Effects of the type of exercise on blood glucose concentrations