Fasting and Exercise-induced Changes in Human Skeletal Muscle

Queen's University

Status: Completed

Conditions: Skeletal Muscle Energetics

Treatments: Other: FAST+EX; Other: FAST

Study type: Interventional

Funder types: Other

Identifiers

NCT03811717

QMPL_HI-01-19

Details and patient eligibility

About

This study examines the impact of increasing energetic stress during an 8-hour fast on metabolic pathways in human skeletal muscle. Specifically, participants will undergo two 8-hour fasting sessions in a randomized crossover fashion, with the addition of low-intensity arm exercise in one of the sessions. Changes in metabolic pathways will be examined in resting (leg) muscle before, during, and after the fast.

Enrollment: 10 patients

Sex: Male

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• recreationally active (no more than 3 hours of weekly physical activity)
• not currently involved in a systematic training program
• body mass index < 30 kg/m2

Exclusion criteria

• presence of cardiometabolic disease
• taking regular oral medication
• current smoker

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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10 participants in 2 patient groups

FAST+EX - FAST

Experimental group

Description:

FAST+EX then FAST alone

Treatment:

Other: FAST+EX

Other: FAST

FAST - FAST+EX

Experimental group

Description:

FAST alone then FAST+EX

Treatment:

Other: FAST+EX

Other: FAST