Fat Absorption and Metabolism After Roux-en-Y Gastric Bypass (FAT-BAR)

Hvidovre University Hospital

Status: Completed

Conditions: Bariatric Surgery

Treatments: Other: Feces collection; Other: Metabolic test; Other: MRS; Other: DXA-scan

Study type: Interventional

Funder types: Other

Identifiers

NCT04859816

FAT-BAR

Details and patient eligibility

About

Using intravenous and oral administration of stable isotope tracers, we will investigate the importance of altered fat absorption and altered whole body fat metabolism for the reduced postprandial systemic TAG concentrations in non-diabetic patients in weight stable phase after RYGB.

Enrollment: 24 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion criteria, RYGB

• Age > 18 years
• RYGB > 12 months prior to inclusion
• Weight stable (± 3 kg during the last month)
• HbA1c < 48 mmol/mol before surgery, and no history of diabetes
• HbA1c < 48 mmol/mol and fasting plasma glucose < 6.1 mmol/l at inclusion

Inclusion criteria, CON

• Age > 18 years
• No former bariatric surgery
• Weight stable (± 3 kg during the last month)
• HbA1c < 48 mmol/mol, fasting plasma glucose < 6.1, and no history of diabetes

Exclusion criteria

• Thyrotoxicosis or inadequately treated hypothyreosis
• Haemoglobin < 6.5 mmol/l at inclusion
• Pregnancy (pregnancy test in fertile woman before enrolment) or breast feeding
• Medication affecting the planned examinations which cannot be paused during the study period.
• Adherence to extreme diets with excessively high or low contributions from certain macronutrients (e.g. ketogenic diet)
• Complications restricting eating behavior (e.g. postprandial hypoglycemia, vomiting or strictures)
• MR contraindications

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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24 participants in 2 patient groups

Roux-en-Y gastric bypass operated participants

Experimental group

Description:

Roux-en-Y gastric bypass operated participants in weight stable phase \> 1 year from surgery

Treatment:

Other: DXA-scan

Other: Metabolic test

Other: Feces collection

Other: MRS

Control participants

Experimental group

Description:

Age, sex, and BMI-matched un-operated participants.

Treatment:

Other: DXA-scan

Other: Metabolic test

Other: Feces collection

Other: MRS