Fat Based Enteral Nutrition for Blood Glucose Control in ICU

Shahid Beheshti University

Status: Completed

Conditions: Hyperglycemia

Treatments: Other: High Fat Enteral Nutrition

Study type: Interventional

Funder types: Other

Identifiers

NCT02584907

1395/34199

Details and patient eligibility

About

In this randomized, double-blind clinical trial, eligible hospitalized ICU patients with EN will be included. Patients will be divided into two groups. The control group with the standard EN and intervention group with high fat EN. 50% of the total fat will be provided by olive oil. Nutritional intake record form will be completed and daily calorie intake will be calculated. High fat EN feeding will be offered for 15 consecutive days maximally. At the end of the study mean blood glucose, duration of hospitalization and rate of infection will be compared in two groups.

Full description

In this randomized, double-blind clinical trial, 88 eligible hospitalized ICU patients with EN will be included. Written consent form will be completed. Physical examination will be done by specialist and nutritional care process will be offered by an RD. Demographic, laboratory and nutritional data will be extracted and entered in prepared form. Venous blood samples will be taken and laboratory values will be measured and recorded at specified times. Patients will be divided into two groups. The control group with the standard EN (Protein; 20% carbohydrate; 50% and fat; 30% from total calories) and intervention group with high fat EN (Protein; 20% carbohydrate; 35% and fat; 45% from total calories). 50% of the total fat will be provided by olive oil. Any feeding rout such as naso - gastric , Percutaneous endoscopic gastrostomy (PEG ) or Percutaneous endoscopic jejunostomy (PEJ) with Intermittent feeding protocol will be accepted feeding method . Nutritional intake record form will be completed and daily calorie intake will be calculated. High fat EN feeding will be offered for 15 consecutive days maximally

Enrollment: 88 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Being on Enteral Nutrition
• BS≥ 200mg/dl
• Without Renal and Liver Failure
• Without Hyperlipidemia and Nephrotic Syndrome
• Without Infection
• Without Obesity

Exclusion criteria

• Death or Discharge before Day 7

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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88 participants in 2 patient groups

High Fat Enteral Nutrition

Experimental group

Description:

Diet in high fat group will be 20% from protein, 45% from fat and 35% from carbohydrate

Treatment:

Other: High Fat Enteral Nutrition

Standered Enteral Nutrition

No Intervention group

Description:

Diet in standard group will be 20% from protein, 30% from fat and 50% from carbohydrate