Fat-induced Release of GLP-1 in Humans

Glostrup University Hospital, Copenhagen

Status: Completed

Conditions: Type 2 Diabetes

Treatments: Dietary Supplement: C8-diet oil; Dietary Supplement: Olive oil; Dietary Supplement: Tributyrin; Dietary Supplement: Carrot

Study type: Interventional

Funder types: Other

Identifiers

NCT02264951

SFAS

Details and patient eligibility

About

This study compared the incretin-releasing effect of C8-diet oil and tributyrin with that of 20 ml olive oil on a molar basis in human volunteers.

Full description

A structured triglyceride (1,3-di-octanoyl-2-oleoyl-glycerol, called C8-diet oil), which upon digestion results in generation of two medium-chain fatty acids and 2-oleoyl-glycerol (2-OG), may lead to activation of GPR119 only, since medium fatty acids are poor agonists for fatty acid receptors.

Enrollment: 12 patients

Sex: Male

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Caucasian healthy male subjects
• Body mass index (BMI) 19 to 25 kg/m2
• Informed consent

Exclusion criteria

• Anaemia
• Diabetes mellitus
• Gastrointestinal diseases or operations interacting with intestinal absorption

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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12 participants in 4 patient groups, including a placebo group

A meal containing carrot and tributyrin

Active Comparator group

Description:

A meal containing 200 g grated carrot and 0.0216 mol tributyrin; blood test taken from 0 - 2 hours postprandial

Treatment:

Dietary Supplement: Tributyrin

Dietary Supplement: Carrot

A meal containing carrot and C8-diet oil

Active Comparator group

Description:

A meal containing 200 g grated carrot and 0.0216 mol of C8-diet oil; blood test taken from 0 - 2 hours postprandial

Treatment:

Dietary Supplement: Carrot

Dietary Supplement: C8-diet oil

A meal containing carrot and olive oil

Active Comparator group

Description:

A meal containing 200 g grated carrot and 0.0216 mol of olive oil; blood test taken from 0 - 2 hours postprandial

Treatment:

Dietary Supplement: Olive oil

Dietary Supplement: Carrot

A meal containing carrot

Placebo Comparator group

Description:

A meal containing 200 g grated carrot; blood test taken from 0 - 2 hours postprandial

Treatment:

Dietary Supplement: Carrot