Fat Metabolites and Gut Hormones

Hvidovre University Hospital

Status: Unknown

Conditions: Gut Hormones; Bariatric Surgery; Overweight and Obesity; Type 2 Diabetes; Dietary Fat

Treatments: Dietary Supplement: C-8 dietary oil; Dietary Supplement: Olive oil; Dietary Supplement: Tricaprylin

Study type: Interventional

Funder types: Other

Identifiers

NCT03223389

CM-FAT-17

Details and patient eligibility

About

To investigate the effects of different fat metabolites on gut hormone secretion in gastric bypass operated subjects and BMI-matched controls.

Full description

Dietary triglycerides are hydrolyzed during digestion to two fatty acids and one 2-monoacyl glycerol. The study will investigate the effects of these different fat components on gut hormone secretion in gastric bypass operated patients and non-operated BMI-matched controls.

Enrollment: 20 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Gastric bypass operated patients:

Inclusion Criteria:

• Uncomplicated gastric bypass surgery performed minimum 12 months prior to study

Exclusion Criteria:

• Type 1 or 2 diabetes mellitus prior to or after gastric bypass surgery
• Pregnancy or breastfeeding
• Haemoglobin levels below 6,5 mM
• Gall bladder removal

Healthy control subjects:

Exclusion Criteria:

• Bariatric surgery or complicated upper abdominal surgery
• Gall bladder removal
• Pregnancy or breastfeeding
• Haemoglobin levels below 6,5 mM
• Co-morbidities or medicine significantly affecting glucose metabolism or appetite regulation

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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20 participants in 2 patient groups

10 gastric bypass operated patients

Experimental group

Description:

3 different oils ingested at separate study days will be tested against each others ability to induce gut hormone secretion.

Treatment:

Dietary Supplement: Tricaprylin

Dietary Supplement: C-8 dietary oil

Dietary Supplement: Olive oil

10 healthy control subjects

Experimental group

Description:

3 different oils ingested at separate study days will be tested against each others ability to induce gut hormone secretion.

Treatment:

Dietary Supplement: Tricaprylin

Dietary Supplement: C-8 dietary oil

Dietary Supplement: Olive oil