Fat Quality on Blood Lipids and Immune Response (NoMa)

University of Oslo

Status: Completed

Conditions: Dietary Prevention

Treatments: Other: Food items

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT01679496

REK 2011/1951

Details and patient eligibility

About

The purpose of this study is to investigate blood LDL-cholesterol and level of inflammatory markers after intake of food items with different fatty acid composition.

Enrollment: 180 patients

Sex: All

Ages: 25 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• hsCRP < 10 mg/L
• total cholesterol 5-7.8 mmol/l(50-70 y)
• total cholesterol 5.0-6.9 mmol/l (30-49 y)
• total cholesterol 5.0-6.1 mmol/l (25-29 y)
• LDL-cholesterol at or above 3.5 mmol/l
• triglycerides at or lower 2.6 mmol/l
• BMI 20-35
• Stable bodyweight last 3 months.

Exclusion criteria

• Chronic diseases
• fasting glucose > 6.0 mmol/l
• increased ASAT and ALAT
• medications affecting lipidmetabolism and inflammation

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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180 participants in 2 patient groups, including a placebo group

Food items

Experimental group

Description:

Food items low in saturated fat and high in polyunsaturated fat

Treatment:

Other: Food items

Control food items

Placebo Comparator group

Description:

Food items containing saturated fat and polyunsaturated fat according to a traditional Norwegian diet

Treatment:

Other: Food items