Fatigability Compared Men and Women Induced According to the Distance Traveled on an Ultra-marathon in the Mountains (UTMB_2019)

Centre Hospitalier Universitaire de Saint Etienne

Status: Completed

Conditions: Ultra-marathon Runners

Treatments: Biological: Urinary sample; Device: Transcranial Magnetic Stimulation (TMS); Other: Neuromuscular tests in isometric mode; Other: Neuromuscular fatigue assessment test; Biological: Blood sample; Other: treadmill

Study type: Interventional

Funder types: Other

Identifiers

NCT04025138

2019-A00736-51 (Other Identifier)

19CH060

Details and patient eligibility

About

Acute physiological consequences of ultra-marathon running are still unknown, particularly in women. Some studies have suggested that the proportion of fatigue attributable to peripheral and central mechanisms varies between males and females; however, results are contradictory.

The results from the investigators of the present experiment in two studies conducted in 2009 and 2012 showed that:

• A large part of fatigue induced by a mountain ultra-marathon could be attributed to central fatigue in males and that,
• Females exhibited less peripheral fatigue in the plantar flexors than males did after a 110-km ultra-trail-running race.

According to the literature, there seems to be a plateau in fatigue after 12-15 hours of running.

Full description

Thus, the main purpose of the present project is to investigate whether sex differences in neuromuscular fatigue in plantar flexors depend on the distance (> 100 km vs < 60 km).

Enrollment: 75 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Subject listed in the race "2019 Mont Blanc Ultra Trail"
• Affiliates or beneficiaries of social security scheme
• Signed consent

Exclusion criteria

• Subject having been injured in the previous 3 months
• Pregnant woman
• Chronic joint diseases
• Chronic or central neurological pathologies
• Taking neuroactive substances that can alter corticospinal excitability
• Contraindication to experimental procedures including Transcranial Magnetic Stimulation (TMS)
• Taking corticosteroids in the previous 3 months

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

75 participants in 4 patient groups

female subjects involved in races over 100 km (F>100)

Experimental group

Description:

Female subjects involved in races over 100 km (F\>100) will be included. They will have neuromuscular tests in isometric mode, Transcranial Magnetic Stimulation (TMS), neuromuscular fatigue assessment test, treadmill, blood sample and urinary sample.

Treatment:

Biological: Urinary sample

Biological: Blood sample

Other: treadmill

Device: Transcranial Magnetic Stimulation (TMS)

Other: Neuromuscular tests in isometric mode

Other: Neuromuscular fatigue assessment test

female subjects involved in races less than 60 km (F<60)

Experimental group

Description:

Female subjects involved in races less than 60 km (F\<60) will be included. They will have neuromuscular tests in isometric mode, Transcranial Magnetic Stimulation (TMS), neuromuscular fatigue assessment test, treadmill, blood sample and urinary sample.

Treatment:

Biological: Urinary sample

Biological: Blood sample

Other: treadmill

Device: Transcranial Magnetic Stimulation (TMS)

Other: Neuromuscular tests in isometric mode

Other: Neuromuscular fatigue assessment test

male subjects involved in races over 100 km (H>100)

Experimental group

Description:

Male subjects involved in races over 100 km (H\>100) will be included. They will have neuromuscular tests in isometric mode, Transcranial Magnetic Stimulation (TMS), neuromuscular fatigue assessment test, treadmill, blood sample and urinary sample.

Treatment:

Biological: Urinary sample

Biological: Blood sample

Other: treadmill

Device: Transcranial Magnetic Stimulation (TMS)

Other: Neuromuscular tests in isometric mode

Other: Neuromuscular fatigue assessment test

male subjects involved in races less than 60 km (H<60)

Experimental group

Description:

Male subjects involved in races less than 60 km (H\<60) will be included. They will have neuromuscular tests in isometric mode, Transcranial Magnetic Stimulation (TMS), neuromuscular fatigue assessment test, treadmill, blood sample and urinary sample.

Treatment:

Biological: Urinary sample

Biological: Blood sample

Other: treadmill

Device: Transcranial Magnetic Stimulation (TMS)

Other: Neuromuscular tests in isometric mode

Other: Neuromuscular fatigue assessment test