ClinicalTrials.Veeva

Menu

Fatigability of Lower Limb Muscle in Older Adults: Protective Effects of Strength Training Exercise in Old Men and Women

Marquette University logo

Marquette University

Status

Enrolling

Conditions

Aging

Treatments

Other: Exercise

Study type

Interventional

Funder types

Other
NIH

Identifiers

NCT03888040
HR-2945
R01AG048262 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

The proposed studies will assess 1) the mechanisms for the age-related increase in fatigability during dynamic exercise (Aims 1 and 2) and 2) the effectiveness of high-velocity resistance training coupled with blood flow restriction (BFR) in improving muscle power output and fatigability in older adults (Aim 3). The first two aims are cross-sectional studies comparing young (18-35 years old) and older adults (≥60 yrs old) to test our central hypothesis that the greater accumulation of metabolites and increase in fatigability in older adults is due to either age-related impairments in skeletal muscle bioenergetics (Aim 1) and/or vascular dysfunction (Aim 2). These two aims will integrate techniques to assess whole-muscle bioenergetics (31P-MRS) and in vivo vascular function (near infrared spectroscopy; NIRS and doppler ultrasonography) with in vitro assessment of single fiber bioenergetics (epifluorescence microscopy) and vasoreactivity of isolated skeletal muscle arterioles (video microscopy). We will then determine whether bioenergetics, vascular function and fatigability are altered in older men and women in response to 8 weeks of resistance exercise training of the lower limb both with and without blood flow restriction (Aim 3).

Enrollment

120 estimated patients

Sex

All

Ages

18 to 100 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • men and women aged 18-40 years and >60 years

Exclusion criteria

  • body mass index ≥40 kg/m2;
  • type 1 or type 2 diabetes;
  • uncontrolled hypertension;
  • active cancer, cancer in remission, or having received treatment for any form of cancer in the previous five years;
  • coronary artery disease;
  • cardiovascular disease (e.g., PAD, PVD);
  • abnormal and untreated thyroid function;
  • chronic and/or regular nonsteroidal anti-inflammatory drugs (NSAID) consumption,
  • tobacco use (includes smoking);
  • any condition that presents a limitation to exercise (e.g., severe arthritis, COPD, neuromuscular disorder, moderate or severe cognitive impairment, Alzheimer's Disease, severe untreated sleep apnea).
  • women who are pregnant or likely to be pregnant.
  • Subjects will be excluded if they have joint pain in the exercising leg or arm. Medication use. Medications currently taken or in the previous year and known to influence muscle mass (e.g., glucocorticoids, testosterone) and cortical and neuromuscular excitability will be exclusionary, while medications that may be prevalent among older adults (e.g., statins) will be accounted for with a covariate statistical model.

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

120 participants in 2 patient groups

Blood Flow Restriction Training
Experimental group
Description:
This leg will then perform low-load resistance training (30% of 1-RM) including 3 sets of 15 knee extensions performed as fast as possible while seated upright in a knee extension weight machine. Sets will be interspersed with 30 seconds rest. This leg will always perform the training with blood flow restriction.
Treatment:
Other: Exercise
Resistance Training Only
Experimental group
Description:
This leg will then perform low-load resistance training (30% of 1-RM) including 3 sets of 15 knee extensions performed as fast as possible while seated upright in a knee extension weight machine. Sets will be interspersed with 30 seconds rest. This leg will always perform the training without blood flow restriction.
Treatment:
Other: Exercise

Trial contacts and locations

1

Loading...

Central trial contact

Christopher W Sundberg, PhD; Sarah Lessila

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location
© Copyright 2025 Veeva Systems