Fatty Acid Biomarkers of Carbohydrate Intake (CARBIO)

Uppsala University

Status: Completed

Conditions: Dyslipidemias

Treatments: Other: High carbohydrate, low sugar diet; Other: Low carbohydrate diet; Other: High carbohydrate, high sugar diet

Study type: Interventional

Funder types: Other

Identifiers

NCT03295448

CARBIO

Details and patient eligibility

About

The overall aim is to investigate if circulating fatty acids and lipids are influenced by alterations in carbohydrate amount and quality.

Full description

In this isocaloric clinical cross-over trial, the investigators aim to investigate if circulating fatty acids and lipids are influenced by alterations in carbohydrate amount and quality. The investigators intend to evaluate if changes in carbohydrate quantity and quality (including sugar) influence circulating even-chain saturated fatty acids or if fatty acid-derived indices of desaturation and de novo lipogenesis are more sensitive biomarkers of carbohydrate intake. By performing untargeted lipidomic analyses, the investigators aim to search for novel lipid biomarkers of carbohydrate quantity and quality. The investigators also want to evaluate the influence of moderate alterations of carbohydrate and sugar intake on lipoproteins, insulin sensitivity, inflammatory proteins.

Enrollment: 19 patients

Sex: All

Ages: 20 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMI 20-38

Exclusion criteria

• abnormal lab tests (assessed by screening and judged by a physician), diabetes, cardiovascular, kidney, liver or malignant disease, and weight-loss (±3kg) the preceding 3 months of screening. Extreme diets, i.e. very-low carbohydrate diets, intermittent fasting, vegan diets or allergic to gluten

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

---

19 participants in 6 patient groups

Fat - Sugar - Fiber

Active Comparator group

Description:

Intervention: consuming diets rich in fat, rich in sugar, and rich in fibers during treatment periods 1, 2, and 3, respectively. Treatment periods are separated by one week of habitual diet.

Treatment:

Other: High carbohydrate, low sugar diet

Other: Low carbohydrate diet

Other: High carbohydrate, high sugar diet

Fat - Fiber - Sugar

Active Comparator group

Description:

Intervention: consuming diets rich in fat, rich in fiber, and rich sugar during treatment periods 1, 2, and 3, respectively. Treatment periods are separated by one week of habitual diet.

Treatment:

Other: High carbohydrate, low sugar diet

Other: Low carbohydrate diet

Other: High carbohydrate, high sugar diet

Sugar - Fiber - Fat

Active Comparator group

Description:

Intervention: Consuming diets rich in sugar, rich in fiber, and rich in fat during treatment periods 1, 2, and 3, respectively. Treatment periods are separated by one week of habitual diet.

Treatment:

Other: High carbohydrate, low sugar diet

Other: Low carbohydrate diet

Other: High carbohydrate, high sugar diet

Sugar - Fat - Fiber

Active Comparator group

Description:

Intervention: Consuming diets rich in sugar, rich in fat, and rich in fiber during treatment periods 1, 2, and 3, respectively. Treatment periods are separated by one week of habitual diet.

Treatment:

Other: High carbohydrate, low sugar diet

Other: Low carbohydrate diet

Other: High carbohydrate, high sugar diet

Fiber - Sugar - Fat

Active Comparator group

Description:

Intervention: Consuming diets rich in fiber, rich in sugar, and rich in fat during treatment periods 1, 2, and 3, respectively. Treatment periods are separated by one week of habitual diet.

Treatment:

Other: High carbohydrate, low sugar diet

Other: Low carbohydrate diet

Other: High carbohydrate, high sugar diet

Fiber - Fat - Sugar

Active Comparator group

Description:

Intervention: consuming diets rich in fiber, rich in fat, and rich in fiber during treatment periods 1, 2, and 3, respectively. Treatment periods are separated by one week of habitual diet.

Treatment:

Other: High carbohydrate, low sugar diet

Other: Low carbohydrate diet

Other: High carbohydrate, high sugar diet