Fatty Acid Composition of Subcutaneous Adipose Tissue in Infants: A Prospective and Observational Study

University Hospital Tuebingen

Status: Unknown

Conditions: Prematurity; Subcutaneous Adipose Tissue

Treatments: Diagnostic Test: PEAPOD; Other: blood; Other: adipose tissue

Study type: Observational

Funder types: Other

Identifiers

NCT03785990

NEO-Adipose tissue

Details and patient eligibility

About

The fatty acid composition in blood and subcutaneous adipose tissue of infants that have an clinical indicated operation is studied.

Full description

Collection of:

• subcutaneous adipose tissue of term infants and preterms after birth and at term during a clinically indicated operation.
• blood before the operation.

Measurement of the fatty acid composition (especially arachidonic acid and docosahexaenoic acid) in subcutaneous adipose tissue and blood.

Aim is to compare the composition of the fatty acids in blood and adipose tissue of preterms at term and term infants. To calculate the fatty acid value in each infant the proportion of adipose tissue is determined with PEAPOD before discharge from hospital.

Enrollment: 21 estimated patients

Sex: All

Ages: Under 6 months old

Volunteers: No Healthy Volunteers

Inclusion criteria

• meeting criteria of the 3 cohorts

Exclusion criteria

• metabolic diseases of the infant
• genetic diseases
• missing agreement for the study

Trial design

21 participants in 3 patient groups

preterms with enterostomy

Description:

GA 23±0/7 - 31±6/7 with clinically indicated operations because of NEC (necrotising enterocolitis) or FIP (focal intestinal perforation). Operation after birth (within 14 days) and at term (enterostomy closure) Analysis of the blood, subcutaneous adipose tissue und total adipose tissue (PEAPOD)

Treatment:

Diagnostic Test: PEAPOD

Other: blood

Other: adipose tissue

preterms without enterostomy

Description:

GA 23±0/7 bis 31±6/7 with a clinically indicated operation (e.g. herniotomy) at term, without any abdominal problems. Analysis of the blood, subcutaneous adipose tissue und total adipose tissue (PEAPOD)

Treatment:

Diagnostic Test: PEAPOD

Other: blood

Other: adipose tissue

term infants

Description:

GA ≥34±0/7 with a clinically indicated operation directly after birth (within 14 days) (e.g. gastroschisis). Analysis of the blood, subcutaneous adipose tissue und total adipose tissue (PEAPOD)

Treatment:

Diagnostic Test: PEAPOD

Other: blood

Other: adipose tissue