Fatty Liver and Ectopic Fat in Overweight and Obese Patients

Centre Hospitalier Universitaire de Nice

Status: Completed

Conditions: Steatohepatitis

Treatments: Procedure: liver biopsy

Study type: Interventional

Funder types: Other

Identifiers

NCT00886301

08-PP-08

Details and patient eligibility

About

The aim of the study is to find new clinico-biological and medical imaging parameters associated with non alcoholic steatohepatitis in overweight and obese patients.

Full description

Non invasive assessment of liver fibrosis and liver inflammation and steatosis is clinically relevant in patients exposed to non alcoholic fatty liver diseases.

The aim of the study is to find new clinico-biological and medical imaging parameters associated with non alcoholic steatohepatitis in overweight and obese patients.

Fatty liver and ectopic fat accumulation will be particularly assessed.

Enrollment: 56 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• BMI between 25 and 40
• ALAT level superior to normal level even after 3 months of diet
• alcohol consumption < 20 g/j for women and < 30 g/j for men

Exclusion criteria

• HIV, hepatitis B virus, hepatitis C virus positive
• known hemochromatosis
• glycemia > 1.26 g/L or under anti-diabetic treatment

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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56 participants in 1 patient group

1

Other group

Description:

obese or overweight patients with fatty liver or ectopic fat

Treatment:

Procedure: liver biopsy