Fatty Liver and Obstructive Sleep Apnea

Shamir Medical Center (Assaf-Harofeh)

Status: Completed

Conditions: Obstructive Sleep Apnea; Non-Alcoholic Fatty Liver Disease

Treatments: Device: Continuous positive airway pressure

Study type: Interventional

Funder types: Other

Identifiers

NCT00730873

135/07

Details and patient eligibility

About

Non-alcoholic fatty liver disease is associated with obstructive sleep apnea. Abnormalities in liver enzymes can improve following continuous positive airway pressure in patients with obstructive sleep apnea. Computerized tomography can be used to quantify fatty liver changes. We hypothesize that continuous positive airway pressure can reduce morphologic fatty liver changes in patients with obstructive sleep apnea and non-alcoholic fatty liver, an that this reduction can be evident using computerized tomography

Sex: All

Ages: 30 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Obstructive sleep apnea, defined as AHI>5/h

Exclusion criteria

• Consumption of more than 20 grams of alcohol per 24 h
• Known autoimmune disease
• Usage of known hepatotoxic drugs
• Medical history positive for viral hepatitis or other chronic liver disease

Trial design

0 participants in 1 patient group

A

Experimental group

Description:

continuous positive airway pressure

Treatment:

Device: Continuous positive airway pressure