FCH PET/MRI Parathyroid Localization

University Health Network, Toronto

Status: Completed

Conditions: Hyperparathyroidism, Primary; 18F-fluorocholine; Positron-Emission Tomography

Treatments: Diagnostic Test: [F-18]-FCH PET/MRI

Study type: Interventional

Funder types: Other

Identifiers

NCT03324893

16-5153

Details and patient eligibility

About

A prospective trial comparing the accuracy of [F-18]-FCH PET/MRI to US and 99mTc-MIBI SPECT/CT for pre-operative parathyroid localization in patients with primary hyperparathyroidism

Enrollment: 47 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥ 18 years
• Biochemically proven primary hyperparathyroidism
• Indication for parathyroidectomy as per institutional guidelines

Exclusion criteria

• Contraindication for MRI as per current institutional guidelines.
• Contraindication for Gadolinium injection as per current institutional guidelines.
• Renal failure
• Inability to lie supine for at least 45 minutes.
• Any participant who is pregnant or breastfeeding.
• Participants receiving erythropoietin (i.e. for hemochromatosis; might lead to false negative results due to stimulation of bone marrow metabolism)
• Familial HPT syndromes
• Participant currently being treated with any cytotoxic chemotherapy

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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47 participants in 1 patient group

[F18]-FCH PET/MRI

Experimental group

Description:

Patients with primary hyperparathyroidism planned for parathyroidectomy

Treatment:

Diagnostic Test: [F-18]-FCH PET/MRI