FCM Analysis GR in Steroid-Treatment Patients

Naval Military Medical University

Status: Unknown

Conditions: Healthy

Study type: Observational

Funder types: Other

Identifiers

NCT00600652

30730114

061210

Details and patient eligibility

About

Monitoring the GR with a GR-MoAb and FITC-Dex probes by FCM would be useful and convenient in determination GR before the steroid treatment in clinical, especially in steroid resistant states, in order to design more efficient clinical treatment protocols.

Full description

In order to assess the efficacy of this method, 100 patients with nephrotic syndrome and systemic lupus erythematosus receiving sufficient prednisolone thereafter and 50 age- and sex-matched normal controls will be studied.

Enrollment: 150 estimated patients

Sex: All

Ages: 15 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Clinical diagnosis of SLE and NS

Exclusion criteria

• Receiving hormone replacement therapy or had received hormone replacement therapy in three months before start of the study
• Received drugs or drinks containing alcohol within one month
• Having symptom such as infection
• Supersensitivity and endocrine disturbance.

Trial design

150 participants in 3 patient groups

1

Description:

glucocorticoid-resistant patients

2

Description:

glucocorticoid-sensitive patients

3

Description:

normal controls