FDG-PET in the Diagnosis of Autoimmune Encephalitis (PEA)

University of Milano Bicocca

Status: Enrolling

Conditions: Autoimmune Encephalitis

Treatments: Diagnostic Test: FDG-PET

Study type: Observational

Funder types: Other

Identifiers

NCT06019975

PEA

Details and patient eligibility

About

The goal of this retrospective observational study is to compare brain fluorodeoxyglucose-positron emission tomography (FDG-PET) of patients with autoimmune encephalitis, normal controls and patients with Alzheimer's disease (AD). The main question it aims to answer is:

•is there a specific pattern of brain metabolism in patients with autoimmune encephalitis Participants data and images will be retrospectively collected from hospital records, and FDG-PET images will be analyzed by means of statistical parametric mapping (SPM). Controls will be selected from validated public databases.

Enrollment: 90 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosis of autoimmune encephalitis according to clinical criteria
• Brain magnetic resonance imaging performed between clinical presentation and treatment
• Cerebrospinal fluid analysis performed between clinical presentation and treatment
• Brain FDG-PET performed between clinical presentation and treatment
• Autoantibodies testing performed between clinical presentation and treatment

Exclusion criteria

• Refusal to give consent for the study

Trial design

90 participants in 1 patient group

Autoimmune Encephalitis patients

Description:

Patients with autoimmune encephalitis admitted to the centers, who underwent a brain FDG-PET during the course of their disease trajectory.

Treatment:

Diagnostic Test: FDG-PET