Feasibility And Efficacy Of An iPad-Based Cognitive Rehabilitation Program In Brain Tumor Patients

University of California San Francisco (UCSF)

Status: Terminated

Conditions: Glioma

Treatments: Behavioral: Device: iPad

Study type: Interventional

Funder types: Other

Identifiers

NCT02783495

NCI-2017-01881 (Registry Identifier)

16106

Details and patient eligibility

About

This pilot clinical trial studies how well an iPad-based cognitive rehabilitation program works in improving quality of life in patients with grade II-III glioma. An iPad-based cognitive rehabilitation program may help to increase patients cognitive function and quality of life, and may provide doctors with valuable information for optimizing care of patients with brain tumors.

Enrollment: 11 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients must have histologically confirmed WHO grade 2 or 3 gliomas.
• Patients must be > 18 years old
• Patients must have a life expectancy > 12 weeks.
• Patients must have a Karnofsky performance status of > 70.
• This study was designed to include women and minorities, but was not designed to measure differences between them. Males and females will be recruited with no preference to gender. Minorities will actively be recruited to participate. No exclusion to this study will be based on race.
• Patients must speak and be able to read English fluently.
• All patients must sign an informed consent indicating that they are aware of the investigational nature of this study. Patients must sign an authorization for the release of their protected health information.
• Patients may not be known to be HIV-positive. HIV testing is not required for study participation.
• Patients must not have a history of any other cancer (except non-melanoma skin cancer or carcinoma in-situ of the cervix), unless in complete remission and off of all therapy for that disease for a minimum of 3 years.
• Patients must be receiving MRI scans at UCSF
• Patients must be clinically stable and off treatment (e.g. radiation or chemotherapy) for ≥ 6 months
• Patients must be ≥ 6 months from craniotomy
• Patients must have subjective complaints of cognitive deficits.
• Patients must have adequate seizure control and be on a stable, or decreasing, dose of anti-epileptics

Exclusion criteria

• Patients who are not able to comply with study and/or follow-up procedures.
• Patients who do not have home access to the Internet.
• Patients who, based on the physician's opinion, are unable to participate in neurocognitive testing and/or neurocognitive rehab secondary to significant neurologic deficit

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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11 participants in 1 patient group

Device: iPad

Experimental group

Description:

Patients with brain tumors receive an iPad with the ReMind app. The patients will use the app to train neurocognitive and compensatory skills for 3 hours per week over the course of 12 weeks (36 hours in total)

Treatment:

Behavioral: Device: iPad