Feasibility and Prognosis of Early Rehabilitation in Patients With ECMO

JinyanXing

Status: Unknown

Conditions: Extracorporeal Membrane Oxygenation

Treatments: Behavioral: rehabilation therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT05083624

QYFYKYLL9121011920

Details and patient eligibility

About

ECMO is increasingly used in critically ill patients with severe circulatory and/or respiratory failure. Because of the catheterization of the femoral artery and femoral vein, usage of sedatives, and occasionally with neuromuscular blockers, ECMO patients are generally considered unsuitable for early activity. However, some recent retrospective studies and a small number of single-center, small-scale prospective studies have shown that early activity of ECMO patients is feasible, and early active activity is associated with recovery of independent function and reduction of delirium incidence.

Enrollment: 100 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ECMO time ≥1 day
• Aged older than16 years old and less than 70 years old

Exclusion criteria

• coma deep
• sedation muscle relaxation (RAAS-3-5)
• Active bleeding deep vein thrombosis
• High dose of vasoactive drugs
• unstable vital signs
• Acute stage of myocardial infarction (within 2d)
• Malignant arrhythmia
• pregnancy

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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100 participants in 2 patient groups

Rehabilitation group

Experimental group

Treatment:

Behavioral: rehabilation therapy

control group

No Intervention group

Description:

adhere to standardized management guidelines for anticoagulation, ventilation, sedation specific to the MICU ECMO population