Feasibility and Safety of Blood-Flow-Restriction Training in Patients With Hemophilia

University Hospital Bonn (UKB)

Status: Invitation-only

Conditions: Hemophilia

Treatments: Device: BFR Exercise (50% of the LOP) while Leg Press Exercise (4 Sets, All out); Device: Control

Study type: Interventional

Funder types: Other

Identifiers

NCT07259356

2024_H

Details and patient eligibility

About

In the course of a cross-over study design, 12 patients with hemophilic arthropathy will perform a training load on the knee extensor muscles. The subjects will each perform one intervention with blood flow restriction and one with a Sham-BFR intervention.

Enrollment: 12 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients with haemophilia
• Ability for an exercise intervention

Exclusion criteria

• Sickle Cell Anemia
• Intravascular stents/bypasses
• Open Wounds/Infections of the lower extremity

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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12 participants in 2 patient groups

Control Condition

Active Comparator group

Description:

Sham-BFR Leg Press Exercise

Treatment:

Device: Control

Intervention Condition

Experimental group

Description:

BFR Leg Press Exercise

Treatment:

Device: BFR Exercise (50% of the LOP) while Leg Press Exercise (4 Sets, All out)