Feasibility Assessment of Risk Stratification and Oral Challenge in Hospitalized Children at Low Risk for Antibiotic Allergy

Vanderbilt University Medical Center

Status: Completed

Conditions: Penicillin Allergy

Treatments: Other: Penicillin Allergy Risk Stratification and Evaluation

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT04441021

200251-2

5K12HL137943-03 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

Children are often reported to have antibiotics allergies, with approximately 10% of the US population labeled as allergic to an antibiotic. Recent studies have demonstrated that a large majority of children with a penicillin allergy label do not have a true IgE-mediated allergy. Appropriately delabeling antibiotic allergies has been shown to improve patient care outcomes and lower health care costs. However, efforts to implement these assessments in practice are lacking, particularly in the hospital setting. Therefore, there is a need for hospital-based risk assessment and delabeling strategies for hospitalized children. The investigator's objective is to determine the feasibility of implementing a hospital-based approach to penicillin allergy risk stratification and evaluation of patients at low-risk for true allergy.

Enrollment: 20 patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients admitted to Vanderbilt children's hospital admitted to a Pediatric Hospital Medicine service with a penicillin allergy reported in their chart who are medically stable

Exclusion criteria

• Known pregnancy
• Patients without a primary care provider

Trial design

20 participants in 1 patient group

Penicillin Allergy Risk Stratification and Evaluation

Description:

This standard of care intervention will provide an antibiotic allergy risk stratification assessment and subsequent amoxicillin oral challenge in patients who stratify as low risk for true allergy

Treatment:

Other: Penicillin Allergy Risk Stratification and Evaluation