Feasibility of Bronchial Washing Fluid for Molecular Testing With Next Generation Sequencing in Lung Cancer

Pusan National University

Status

Completed

Conditions

Lung Cancer

Treatments

Diagnostic Test: Ultrathin bronchoscopy with intratumoral washing

Study type

Interventional

Funder types

Other

Identifiers

NCT06141005

2310-011-132

Details and patient eligibility

About

This is a single center, clinical trial evaluating the relevance of intratumoral washing for detection of generic alteration with Next Generation Sequencing.

Full description

This is a prospective, single-arm, open-label study to assess evaluate the relevance of intratumoral washing by ultrathin bronchoscopy (outer diameter; 3mm) for detection of genetic alterations using Next Generation Sequencing in patients with NSCLC.

Enrollment

65 patients

Sex

All

Ages

20+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Age ≥ 20 years
Obtained written informed consent
No contraindication to bronchoscopy
Subjects suspected of having lung cancer on computed tomography or diagnosed with lung cancer by histology or cytology
Subjects planning to undergo tissue or liquid biopsy for genetic alteration with Next Generation Sequencing

Exclusion criteria

Subjects who withdraw informed consent
Subjects who are unable to undergo liquid biopsy (plasma) and tissue biopsy for genetic alteration with Next Generation Sequencing based on the investigator's judgement
Subjects diagnosed with a cancer other than non-small cell lung cancer from the lung tissue lesion
Subjects diagnosed with a benign lesion from the lung tissue lesion