Feasibility of Measuring Exercise's Effects on Molecular Mechanisms of Disease Progression in Prostate Cancer (EMMPC)

V

Vancouver Prostate Centre (VPC)

Status

Active, not recruiting

Conditions

Prostate Cancer

Treatments

Other: Exercise

Study type

Interventional

Funder types

Other

Identifiers

NCT02481648
EMMPC

Details and patient eligibility

About

The investigators aim to evaluate the feasibility of a larger clinical trial assessing an exercise program during the "teachable moment" in patients with prostate cancer and measuring its effect on tumor apoptosis signaling, lipogenesis and steroidogenesis. Participants will be randomized between a 4-12 week exercise program or to standard of care only. Participants will be assessed at screening, baseline (day 0), throughout the trial intervention (days 1-84), post-intervention visit (prior to radical prostatectomy) and final study visit 6-months post-radical prostatectomy. At each assessment, physical, biological samples and psychosocial assessments will take place.

Enrollment

20 patients

Sex

Male

Ages

19+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Completed Pre-Screening Consent Form
  • Men with CaP, who are deemed suitable by a urologist for RP
  • Engaging in <90 minutes/week of moderate-to-vigorous exercise
  • BMI <40
  • Age >19
  • Able to speak and read English (to be able to complete questionnaires)
  • Willing to comply with all study procedures (including committing to twice-weekly visits to the study exercise facility and exercise at home) and be available for the duration of the study
  • Provide signed and dated informed consent form

Exclusion criteria

• Men with a medical, musculoskeletal condition or use of mobility aid that prevents participation in the exercise intervention.

Trial design

Primary purpose

Supportive Care

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

20 participants in 2 patient groups

ARM1: Exercise Intervention
Experimental group
Description:
The exercise program is a 4-12 weeks progressive combined resistance and aerobic exercise for participants from time of diagnosis to RP. Participants will undergo twice weekly group-training (four-six participants/group) combined aerobic-resistance sessions (1hr per session), supervised by trained exercise therapists. In addition, participants will undergo home-based aerobic exercise independently three times a week with the goal to meet the current physical activity guidelines for cancer survivors (150min/week of moderate intensity aerobic activity and two resistance training sessions per week). Participants will also be supplied with the Canadian Physical Activity and Sedentary Behavior Guidelines Handbook and accompanying Log Sheets.
Treatment:
Other: Exercise
ARM2: Control Group
No Intervention group
Description:
Participants will be asked to exercise as they normally would and will be asked to record their exercise activity on provided activity logs.

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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