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Feasibility of Online MR-guided Radiotherapy on a 1.5T MR-Linac

U

University Hospital Tuebingen

Status

Enrolling

Conditions

Breast Cancer
Esophageal Cancer
Head and Neck Cancer
Prostate Cancer
Liver Cancer
Oligometastasis
Rectal Cancer

Treatments

Diagnostic Test: Imaging on the MR Linac
Radiation: Radiotherapy on the MR-Linac

Study type

Interventional

Funder types

Other

Identifiers

NCT04172753
659/2017BO1

Details and patient eligibility

About

This study investigates the feasibility of imaging and treatment on a novel 1.5 T MR-Linac radiotherapy hybrid device.

Full description

Novel hybrid devices combine magnetic resonance imaging (MRI) and a linear accelerator in a single device. The superior soft tissue contrast compared with cone-beam computed tomography based treatment and the possibility for daily plan adaptation promise a higher precision of treatment, better target volume coverage and normal tissue sparing. In a first step the present study will test the feasibility of imaging and treatment on the 1.5 T MR-Linac.

Enrollment

472 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • existing indication for radiation therapy
  • minimum age 18 years, no upper age limit
  • capacity for consent
  • Informed consent

Exclusion criteria

  • contraindication for MRI (claustrophobia, metallic implants not applicable for MRI
  • pregnancy

Trial design

Primary purpose

Treatment

Allocation

Non-Randomized

Interventional model

Single Group Assignment

Masking

None (Open label)

472 participants in 9 patient groups

Rectal and anal cancer
Experimental group
Description:
In this arm patients with rectal and anal cancer are recruited.
Treatment:
Radiation: Radiotherapy on the MR-Linac
Prostate cancer
Experimental group
Description:
In this arm patients with prostate cancer are recruited.
Treatment:
Radiation: Radiotherapy on the MR-Linac
Head and neck cancer
Experimental group
Description:
In this arm patients with head and neck cancers are recruited.
Treatment:
Radiation: Radiotherapy on the MR-Linac
Esophageal cancer
Experimental group
Description:
In this arm patients with esophageal cancer are recruited.
Treatment:
Radiation: Radiotherapy on the MR-Linac
Breast Cancer
Experimental group
Description:
In this arm patients with breast cancer are recruited.
Treatment:
Radiation: Radiotherapy on the MR-Linac
Central nervous system tutors
Experimental group
Description:
In this arm patients with tumors of the central nervous system are recruited.
Treatment:
Radiation: Radiotherapy on the MR-Linac
Palliative treatments
Experimental group
Description:
In this arm patients with palliative treatments are recruited.
Treatment:
Radiation: Radiotherapy on the MR-Linac
Other
Experimental group
Description:
In this arm patients with other tumors are recruited.
Treatment:
Radiation: Radiotherapy on the MR-Linac
Imaging only
Experimental group
Description:
In this arm patients receive only imaging on the MR-Linac
Treatment:
Diagnostic Test: Imaging on the MR Linac

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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