Feasibility of Online MR-guided Radiotherapy on a 1.5T MR-Linac

University Hospital Tuebingen

Status: Enrolling

Conditions: Breast Cancer; Esophageal Cancer; Head and Neck Cancer; Prostate Cancer; Liver Cancer; Oligometastasis; Rectal Cancer

Treatments: Diagnostic Test: Imaging on the MR Linac; Radiation: Radiotherapy on the MR-Linac

Study type: Interventional

Funder types: Other

Identifiers

NCT04172753

659/2017BO1

Details and patient eligibility

About

This study investigates the feasibility of imaging and treatment on a novel 1.5 T MR-Linac radiotherapy hybrid device.

Full description

Novel hybrid devices combine magnetic resonance imaging (MRI) and a linear accelerator in a single device. The superior soft tissue contrast compared with cone-beam computed tomography based treatment and the possibility for daily plan adaptation promise a higher precision of treatment, better target volume coverage and normal tissue sparing. In a first step the present study will test the feasibility of imaging and treatment on the 1.5 T MR-Linac.

Enrollment: 472 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• existing indication for radiation therapy
• minimum age 18 years, no upper age limit
• capacity for consent
• Informed consent

Exclusion criteria

• contraindication for MRI (claustrophobia, metallic implants not applicable for MRI
• pregnancy

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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472 participants in 9 patient groups

Rectal and anal cancer

Experimental group

Description:

In this arm patients with rectal and anal cancer are recruited.

Treatment:

Radiation: Radiotherapy on the MR-Linac

Prostate cancer

Experimental group

Description:

In this arm patients with prostate cancer are recruited.

Treatment:

Radiation: Radiotherapy on the MR-Linac

Head and neck cancer

Experimental group

Description:

In this arm patients with head and neck cancers are recruited.

Treatment:

Radiation: Radiotherapy on the MR-Linac

Esophageal cancer

Experimental group

Description:

In this arm patients with esophageal cancer are recruited.

Treatment:

Radiation: Radiotherapy on the MR-Linac

Breast Cancer

Experimental group

Description:

In this arm patients with breast cancer are recruited.

Treatment:

Radiation: Radiotherapy on the MR-Linac

Central nervous system tutors

Experimental group

Description:

In this arm patients with tumors of the central nervous system are recruited.

Treatment:

Radiation: Radiotherapy on the MR-Linac

Palliative treatments

Experimental group

Description:

In this arm patients with palliative treatments are recruited.

Treatment:

Radiation: Radiotherapy on the MR-Linac

Other

Experimental group

Description:

In this arm patients with other tumors are recruited.

Treatment:

Radiation: Radiotherapy on the MR-Linac

Imaging only

Experimental group

Description:

In this arm patients receive only imaging on the MR-Linac

Treatment:

Diagnostic Test: Imaging on the MR Linac