Feasibility of Structured Resistance Training After Lower Extremity Fracture

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Status: Not yet enrolling

Conditions: Lower Extremity Fractures

Treatments: Behavioral: Structured Supervised Resistance Training and Coaching Program

Study type: Interventional

Funder types: Other

Identifiers

NCT07629180

RETRAIN Study

LHSCRI (Other Identifier)

Details and patient eligibility

About

Adults recovering from surgically managed diaphyseal femur or tibia fractures often experience persistent weakness, pain, and functional limitations despite successful fracture healing. This prospective, non-randomized pilot study evaluates the feasibility and acceptability of a structured, supervised resistance training program initiated approximately 12 weeks after surgery, compared with usual postoperative care alone. The study will assess recruitment, adherence, retention, and protocol fidelity, and will collect exploratory patient-reported and physical function outcomes to inform the design of a future randomized controlled trial.

Full description

This is a prospective, non-randomized, controlled pilot feasibility study enrolling adults aged 20 to 65 years with isolated diaphyseal femur or tibia fractures treated surgically with locked intramedullary nail fixation. Participants will be recruited from routine postoperative fracture clinic visits and enrolled approximately 10 to 14 weeks after injury, once fracture healing has progressed sufficiently to allow full weight bearing and independent participation in supervised exercise.

Enrollment: 40 estimated patients

Sex: All

Ages: 20 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adults aged 20 to 65 years
• Diaphyseal femur or tibia fracture treated surgically with locked intramedullary nail fixation
• Cleared for full weight bearing with adequate fracture healing and no major complications
• Able to provide written informed consent in English without an interpreter
• Able to understand instructions and safely participate in supervised exercise

Exclusion criteria

• Bilateral fractures or open fractures; Polytrauma
• Cognitive impairment affecting participation or ability to provide informed consent
• Severe cardiac, respiratory, or neurological conditions that preclude exercise participation
• Chronic pain syndromes or recent opioid dependence
• Pre-existing severe lower limb disability
• Requires an interpreter for consent or cannot follow exercise instructions independently
• Unable to provide consent due to language barrier

Trial design

Primary purpose: Supportive Care

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

40 participants in 2 patient groups

Structured Resistance Training Program

Experimental group

Description:

Participants with surgically managed diaphyseal femur or tibia fractures who participate in a 12-week structured, supervised resistance training and activity program initiated approximately 12 weeks after surgery, in addition to usual postoperative care.

Treatment:

Behavioral: Structured Supervised Resistance Training and Coaching Program

Usual Care Control

No Intervention group

Description:

Participants with surgically managed diaphyseal femur or tibia fractures who receive usual postoperative care without participation in the structured supervised exercise or coaching program.