Feasibility of VMAT and CBCT for Head and Neck Carcinomas

British Columbia Cancer Agency

Status and phase: Completed; Phase 1

Conditions: Head and Neck Carcinoma

Treatments: Radiation: VMAT with CBCT; Radiation: VMAT with kV-ray

Study type: Interventional

Funder types: Other

Identifiers

NCT01384890

VMAT, CBCT for H&N ca

Details and patient eligibility

About

This will be a prospective longitudinal study describing clinical throughput metrics and patient reported quality of life outcome measures for patients undergoing Volumetric modulated arc therapy (VMAT) with and without Cone-beam computed tomography (CBCT) for head and neck carcinoma at the British Columbia Cancer Agency.

1. VMAT for the treatment of patients with HNC will provide opportunities for image-guided radiotherapy using CBCT online correction to reduce systematic and random error.
2. Analysis of patient reported quality of life outcomes during VMAT, with and without CBCT acquisition, will be hypothesis generating.

Enrollment: 20 patients

Sex: All

Ages: 18+ months old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age greater than 18 years
• undergoing radical radiation therapy for head and neck carcinoma at the BC Cancer Agency

Exclusion criteria

• treatment being offered is not for curative intent
• patient has received previous radiation for head and neck cancer
• patient has systemic lupus erythematosis or scleroderma
• patients has other autoimmune connective tissue disorders

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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20 participants in 2 patient groups

VMAT with CBCT

Experimental group

Description:

Volumetric modulated arc therapy (VMAT) with cone-beam computed tomography position (CBCT) verification

Treatment:

Radiation: VMAT with CBCT

VMAT with kV-ray

Active Comparator group

Description:

Volumetric modulation arc therapy (VMAT) with kV-ray position verification

Treatment:

Radiation: VMAT with kV-ray