Feasibility, Safety and QoL After Merendino Procedure (MER)

Kantonsspital Liestal

Status: Completed

Conditions: Benign or Early Malignant Lesion of the Distal Esophagus or Gastro-esophageal Junction Requiring Surgical Resection

Treatments: Other: EORTC and QLQ-C30 / QLQ-OES24 questionnaire

Study type: Observational

Funder types: Other

Identifiers

NCT02855333

KLiestal

Details and patient eligibility

About

The purpose of this study is to analyse retrospectively the early postoperative and functional outcome of patients (pts) after Merendino procedure for benign or early malignant lesions of the distal part of the esophagus or the gastroesophageal junction.

Full description

Between 2004 and 2013, 14 pts had transhiatal resection of median 8 (6-10) cm of distal esophagus including the gastroesophageal junction. Locoregional lymphadenectomy was performed in all patients with (suspected) early adenocarcinoma. In case of vagus nerve resection, pyloromyectomy and cholecystectomy were done. A pediculated isoperistaltic jejunal segment of 15-18 cm length was interponed between esophageal stump and remaining stomach by end-to-side anastomoses. At least one postoperative contrast examination of the anastomoses was done in all pts. Quality of life was assessed by using the EORTC QLQ-OES18 survey, recording patients' general activity and condition and specific gastrointestinal symptoms.

Enrollment: 26 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• alive
• MER or CON procedure
• informed consent
• CON patients were matched according to diagnosis, Age and ASA score

Exclusion criteria

• withdrawal of informed consent
• legal incapacity
• limitations in mental state or medical condition precluding questioning (only QoL data)

Trial design

26 participants in 2 patient groups

Merendino Group (MER)

Description:

Patients who underwent merendino procedure for benign or early malignant lesions of the distal esophagus/gastroesophageal junction Perioperative data and EORTC and QLQ-C30 / QLQ-OES24 questionnaire

Treatment:

Other: EORTC and QLQ-C30 / QLQ-OES24 questionnaire

Control Group (CON)

Description:

Patients who underwent alternative surgery for benign or early malignant lesions of the distal esophagus/gastroesophageal junction Perioperative data and EORTC and QLQ-C30 / QLQ-OES24 questionnaire

Treatment:

Other: EORTC and QLQ-C30 / QLQ-OES24 questionnaire