Features of the Clinical Course and Prognosis in Patients With Idiopathic Pulmonary Hypertension When Using Modern Strategies of Specific Therapy

Russian Cardiology Research and Production Center

Status: Active, not recruiting

Conditions: Idiopathic Pulmonary Arterial Hypertension

Study type: Observational

Funder types: Other

Identifiers

NCT06587074

SHAM-3232

Details and patient eligibility

About

This study will be performed based on a retrospective analysis of the cases of 150-170 patients with IPAH observed at the Research Institute of Clinical Cardiology over the past 10 years, for a comparative assessment of the survival of groups of patients with IPAH diagnosed in the period 2004-2013 and 2014-2023.

The demographic, clinical, functional, hemodynamic characteristics of patients, comorbidity, blood biomarker levels, received PAH-specific and symptomatic therapy will be assessed in order to determine the clinical characteristics of patients with IPAH.

The prospective part of study will include 50 patients with IPAH.

Enrollment: 150 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age over 18 years;
• verified diagnosis of IPAH

Exclusion criteria

• age under 18 years;
• Other etiology op PAH,
• ischemic heart disease confirmed by MSCT of the coronary arteries or coronary angiography;
• diseases of the musculoskeletal system that prevent 6MWT
• severe liver dysfunction (more than 9 points on the Child-Pugh scale, class C)
• severe renal dysfunction (CC less than 15 ml/min), need for hemodialysis

Trial design

150 participants in 2 patient groups

Group 1

Group 2