Fecal Microbiota Transplant for Neuroblastoma in a Single Patient

ProgenaBiome

Status

Conditions: Neuroblastoma (Measurable Disease); Neuroblastoma (NBL); Neuroblastoma; Neuroblastoma in Children; Neuroblastoma Recurrent; Neuroblastoma (NB); Neuroblastoma. CNS

Treatments: Biological: Fecal Microbial Transplantation

Study type: Expanded Access

Funder types: Other

Identifiers

NCT07223606

IND 31935 (Other Identifier)

Details and patient eligibility

About

This study uses fecal microbiota transplant (FMT) to correct gut microbiome dysbiosis prior to and during standard-of-care neuroblastoma treatment

Full description

Patients with neurobastoma and concurrent dysbiosis showing a bifidobacteria-bacteroides gap will undergo fecal microbiota transplant as an adjunctive to standard-of-care oncology treatment.

Sex: All

Ages: 5+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• willingness of parent/guardian to sign ICF
• diagnosis of neuroblastoma
• dysbiosis of the gut microbiome

Exclusion criteria

• parent/guardian unwilling to sign ICF
• dysbiosis does not show a bifidobaceteria-bacteroides gap
• severely abnormal screening lab values