Fecal Microbiota Transplantation for Liver Failure

Ningbo Medical Center Lihuili Hospital

Status

Enrolling

Conditions

Liver Failure

Treatments

Other: fecal microbiota transplantation

Study type

Interventional

Funder types

Other

Identifiers

NCT05170971

KJ2019PJ021

Details and patient eligibility

About

To investigate the safety, adverse reactions and therapeutic effects of fecal microbiota transplantation on patients with liver failure;to investigate the effect of fecal microbiota transplantation on the intestinal microecology and "gut-liver axis immune system" of liver failure, and further optimization of fecal microbiota transplantation technology.

Enrollment

60 estimated patients

Sex

All

Ages

18 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Patients willing to sign informed consent
Patients aged 18-65
According to the diagnosis standard of liver failure in the guide for diagnosis and treatment of liver failure (2018 Edition), the eligible patients are included, that is, on the basis of chronic liver disease, the syndrome with acute jaundice deepening and coagulation dysfunction as the manifestation of liver failure caused by various inducements can be combined with complications such as Hepatoencephalopathy, ascites, electrolyte disorder, infection, hepatorenal syndrome, hepatopulmonary syndrome, etc And extrahepatic organ failure. The patient's jaundice deepened rapidly, the serum TBIL ≥ 10 × ULN or the daily rise ≥ 17.1 μ mol / L; there was bleeding, PTA ≤ 40% (or INR ≥ 1.5)

Exclusion criteria

Patients with severe heart failure, COPD, cerebrovascular accident, nephrotic syndrome, etc;
Patients with gastrointestinal bleeding, pulmonary infection, septicemia, etc
Patients with liver cancer, lung cancer, lymphoma and other malignant tumors
Patients taking anticoagulants, mental diseases and immune diseases for a long time
Pregnant or lactating women.