Feedback Loop Between Intracranial Atherosclerosis and Cerebral Small Vessel Disease

Chinese PLA General Hospital (301 Hospital)

Status

Enrolling

Conditions

ICAS - Intracranial Atherosclerosis

Cerebral Small Vessel Diseases

Treatments

Diagnostic Test: Magnetic resonance imaging

Study type

Observational

Funder types

Other

Identifiers

NCT05677607

301Brainmax

Details and patient eligibility

About

The present study aims at verifying the mutual effects between intracranial large artery atherosclerosis and cerebral small vessel disease on disease progression and prognosis by magnetic resonance imaging, and providing biomarkers for the early prevention and treatment of cerebrovascular disease.

Full description

Cerebrovascular disease is the most common cause of death worldwide. There is a close link in structure and function between the intracranial large arteries and cerebral small vessels. Moreover, growing evidences have demonstrated that large artery atherosclerosis often coexists with small vessel disease, which may deteriorate the clinical outcomes of stroke and dementia. The mutual feedback mechanism between them is not fully understood. The present study focuses on the mechanism of mutual feedback between large artery atherosclerosis and cerebral small vessel disease by using magnetic resonance imaging. The study may provide biomarkers for the early prevention and treatment of cerebrovascular disease.

Enrollment

300 estimated patients

Sex

All

Ages

30+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Age ≥ 18 years
At least one intracranial artery ≥ 50% atherosclerotic stenosis
Modified Rankin Scale < 2
Mini-mental State Examination > 24

Exclusion criteria

Concurrent ipsilateral extracranial artery ≥ 50% stenosis
Pregnant women
Contraindications to magnetic resonance examination (patients with pacemakers, nerve stimulators, artificial metal heart valves and other metal foreign bodies)