Femoral and Epidural Block After Total Knee Arthroplasty

Aydin Adnan Menderes University

Status and phase: Completed; Early Phase 1

Conditions: Chronic Postoperative Pain; Acute Postoperative Pain

Treatments: Other: DN4 test; Procedure: epidural block; Other: The SF 12 test; Other: HAD scale; Other: Visual analogue score; Procedure: femoral block

Study type: Interventional

Funder types: Other

Identifiers

NCT02115945

SARI-01

Details and patient eligibility

About

Total knee prosthetic replacement causes severe postoperative pain. Various analgesic techniques have been used in pain control. Comparison of epidural and femoral nerve block is lacking, furthermore effect on chronic pain is unclear. The investigators aimed to compare the effects of epidural and femoral block on acute and chronic postoperative pain.

Full description

Background and aim Total knee prosthetic replacement causes severe postoperative pain. Various analgesic techniques have been used in pain control. Comparison of epidural and femoral nerve block is lacking, furthermore effect on chronic pain is unclear. The investigators aimed to compare the effects of epidural and femoral block on acute and chronic postoperative pain.

Methods The study was of randomized, prospective, and double-blind design and was conducted with 80 patients who had undergone total knee prosthetic replacement surgery with the insertion of a femoral nerve block or epidural block catheter to initiate postoperative analgesia. One-sided spinal anesthesia was performed in all the patients. Postoperative pain control was achieved with the administration via catheter using bupivacaine for patient-controlled analgesia. Acute postoperative pain was evaluated in the first 24 hours and chronic postoperative pain in the 1st and 3rd months following surgery. The anxiety/depression scale was used to assess anxiety and depression, the SF 12 test was used to evaluate quality of life, and the DN4 test was employed at patient visits at the 1st and 3rd months.

Enrollment: 40 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Clinical diagnosis of total knee arthroplasty

Exclusion criteria

• Patients with pain syndromes
• Patients using routinely medications for pain

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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40 participants in 2 patient groups

epidural block

Experimental group

Description:

Visual anlogue score vas used to evaluate pain. The anxiety/depression scale (HAD) was used to assess anxiety and depression. The SF 12 test (SHORT FORM 12) was used to evaluate quality of life. The DN4 test was used to evaluate neuropathic pain.

Treatment:

Other: Visual analogue score

Other: HAD scale

Other: The SF 12 test

Other: DN4 test

Procedure: epidural block

femoral block

Active Comparator group

Description:

Visual anlogue score vas used to evaluate pain. The anxiety/depression scale (HAD) was used to assess anxiety and depression. The SF 12 test (SHORT FORM 12) was used to evaluate quality of life. The DN4 test was used to evaluate neuropathic pain.

Treatment:

Other: Visual analogue score

Other: HAD scale

Other: The SF 12 test

Other: DN4 test

Procedure: femoral block