Fertility After Diagnosis and Management of Acquired Uterine Arteriovenous Malformation (MAVUFERT)

Rennes University Hospital

Status: Completed

Conditions: Arteriovenous Malformations

Treatments: Other: Telephone interview

Study type: Observational

Funder types: Other

Identifiers

NCT03656211

2017-A01760-53 (Other Identifier)

35RC17_3026

Details and patient eligibility

About

Uterine arteriovenous malformations (UAVM) are short circuits between systemic arterial and venous networks within the uterus. They are congenital or acquired (in the course of an endo-uterine gesture such as curettage or interventions such as caesareans or myomectomies).

They can be manifested by severe metrorrhagia that can go as far as to put the patient's vital prognosis at risk.

There are no recommendations for the management of UAVM since this pathology is rare and therefore series are performed with few cases. If some of these UAVM disappear spontaneously after a therapeutic abstention, when the clinical context allows it, in case of symptomatic UAVM, a selective embolization with arteriography is often carried out to postpone the hysterectomy of hemostasis.

There are also more marginal management options such as Gonadotropin-Releasing Hormone agonists, methotrexate or curettage that are decided on a case by case basis depending on the symptoms and protocols of each medical team.

Regarding subsequent fertility and pregnancy outcomes after conservative treatment, the number of studies is even lower.

Enrollment: 15 patients

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Major patient
• Diagnosis of UAVM, symptomatic or not, between January 1st, 2000 and March 30th, 2017 confirmed by imagery performed at the Rennes University Hospital
• Not against her participation in research

Exclusion criteria

• Minor patient at the time of diagnosis
• congenital UAVM
• Uterine malformation
• Patient under legal protection (guardianship, curatorship, safeguard of justice).

Trial design

15 participants in 1 patient group

Patients with UAVM

Description:

All patients who have been diagnosed with UAVM (symptomatic or non-symptomatic) between January 1, 2000 and March 30, 2017, and confirmed by an imaging examination. Telephone interview

Treatment:

Other: Telephone interview