Fertility After Prostate Brachytherapy

East and North Hertfordshire NHS Trust

Status: Unknown

Conditions: Prostate Cancer

Study type: Observational

Funder types: Other

Identifiers

NCT04278443

RD2016-50

Details and patient eligibility

About

Although brachytherapy toxicity data on erectile dysfunction, urethral dysfunction and bladder and bowel impact has been collected for a number of years, there is limited information on its effect on male fertility. This study aims to investigate the effect of brachytherapy on fertility

Full description

Brachytherapy is a commonly employed technique in the treatment of all prostate cancer risk groups. It delivers a high radiation localised to the prostate gland. The effects of this on fertility have not been systematically studied. An increasing number of younger men for whom fertility is an issue are being diagnosed with prostate cancer and may be offered brachytherapy amongst their treatment choices. This study therefore addresses this issue with a systematic evaluation of sperm count and quality before and after both high dose rate and low dose rate brachytherapy.

Enrollment: 40 estimated patients

Sex: Male

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Male
• 18 years or older
• Receiving brachytherapy monotherapy; High or Low dose rate
• Ability to ejaculate
• Able to provide written informed consent

Exclusion criteria

• History of infertility or vasectomy
• Previous chemotherapy or pelvic radiotherapy
• Prior use of androgen deprivation therapy
• 5 alpha-reductase inhibitors within the last 4 months
• Alpha blockers within 7 days of semen collection

Trial design

40 participants in 2 patient groups

Low dose rate brachytherapy

Description:

20 patients receiving low dose rate brachytherapy

High dose rate brachytherapy

Description:

20 patients receiving high dose rate brachytherapy.