Fertility and Ovarian Reserve Function in the Patient With Inflammatory Bowel Disease

Sun Yat-sen University

Status: Unknown

Conditions: Fertility Disorders; Ovarian Reserve Function; Pregnancy Outcomes

Treatments: Other: Anti Mueller hormone; Other: Estrogen; Other: Follicle-Stimulating Hormone; Other: Antral alveolar cell count

Study type: Interventional

Funder types: Other

Identifiers

NCT03269916

SixthSunYetSen

Details and patient eligibility

About

ECCO consensus, the fertility would decline in activity inflammatory bowel disease(IBD), because of anus lesions and pelvic abscess, or who underwent surgery, especially in patients with ileal pouch anal anastomosis (IPAA) storage.The study on fertility in inflammatory bowel disease were almost epidemiological investigation, the lack of objective evaluation of fertility, and controversial.This study will explore the fertility, ovarian reserve function and the pregnancy outcomes in patients with IBD.

Enrollment: 80 estimated patients

Sex: Female

Ages: 17 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Inflammatory bowel disease
2. 17-40 years old
3. female

Exclusion criteria

1. in pregnancy or lactation
2. a drug that has been or is being used known to affect ovarian function, such as cyclophosphamide
3. reproductive system diseases unrelated to disease or treatment of inflammatory bowel disease, such as hysterectomy, pelvic radiotherapy after surgery, after ovariectomy, polycystic ovary syndrome, endometriosis, ovarian granulosa cell tumor
4. other endocrine diseases, such as prolactin, hyperthyroidism, lead to endocrine disorders;
5. malignant tumor

Trial design

Primary purpose: Other

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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80 participants in 2 patient groups

IBD patients

Experimental group

Description:

IBD patients, 17-40 years old, female

Treatment:

Other: Antral alveolar cell count

Other: Estrogen

Other: Follicle-Stimulating Hormone

Other: Anti Mueller hormone

healthy control

Other group

Description:

17-40 years old , female, without any gynecological disease

Treatment:

Other: Antral alveolar cell count

Other: Estrogen

Other: Follicle-Stimulating Hormone

Other: Anti Mueller hormone