Fertility Study of Women With Chronic Inflammatory Rheumatism (FERTIRHUM)

Toulouse University Hospital

Status: Unknown

Conditions: Chronic Juvenile Arthritis; Arthritis, Psoriatic; Ankylosing Spondylitis; Arthritis, Rheumatoid

Treatments: Other: Questionnaire about fertility

Study type: Observational

Funder types: Other

Identifiers

NCT03452735

RC31/17/0446

2017-A03539-44 (Other Identifier)

Details and patient eligibility

About

Etiopathogenesis of Chronic inflammatory rheumatisms (CIR) includes genetic, autoimmune and environmental factors. Their impact on the quality of life is important, leading to a sometimes severe disability. Thus they are likely to affect female fertility through several mechanisms, including autoimmune since the association between immunity and fertility has already been demonstrated in other autoimmune diseases.

This study wants to evaluate and compare the birth rate between CIR and control group.

Full description

Data collection will be carried out using a questionnaire submitted to women in charge of the rheumatology department of the University Hospital of Toulouse and having agreed to participate:

• women with Rheumatoid arthritis, Psoriatic arthritis, Ankylosing spondylitis or Chronic juvenile arthritis for the chronic inflammatory rheumatism group
• women with a mechanical rheumatic pathology for the control group

The primary endpoint was birth rate after spontaneous or induced pregnancy in patients who attempted to procreate, in the CIR group and in the control group.

Enrollment: 2,900 estimated patients

Sex: Female

Ages: 18 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient with Rheumatoid arthritis, Psoriatic arthritis, Ankylosing spondylitis, Chronic juvenile arthritis, Chronic Inflammatory Rheumatism
• Patient diagnosed before the age of 40
• Patient having given her no opposition to her participation in research
• For the control group: patient not suffering from chronic inflammatory rheumatism, having consulted in Rheumatology for a mechanical pathology

Exclusion criteria

• Patient> 40 years old at the time of diagnosis
• Patient with insufficient medical data (treatments)

Trial design

2,900 participants in 2 patient groups

patients diagnosed before age 40

Description:

Patient between 18 and 50 years-old with Rheumatoid arthritis, Psoriatic arthritis, Ankylosing spondylitis, Chronic juvenile arthritis, Chronic Inflammatory Rheumatism who will answer to a questionnaire about fertility

Treatment:

Other: Questionnaire about fertility

Control Group

Description:

Patient between the ages of 18 and 50 years, not diagnosed with Chronic inflammatory rheumatism, having consulted in Rheumatology for a mechanical pathology, presenting no chronic pathology, having no chemo or radiotherapy or immunosuppressive therapy, or pelvic surgery before age 40 years who will answer to a questionnaire about fertility

Treatment:

Other: Questionnaire about fertility