Fertilizations With Immotile Sperm: Pentoxyphylline Activation Alone, or With Chemical Oocyte Activation (PXN)

Rambam Health Care Campus

Status and phase: Withdrawn; Phase 4

Conditions: Infertility

Treatments: Biological: PXN sperm treatment; Biological: Sperm activation with PXN and oocyte activation

Study type: Interventional

Funder types: Other

Identifiers

NCT02051075

RMB 0443-13

0443-13-RMB (Other Identifier)

Details and patient eligibility

About

Immotile sperm is a rather frequent problem encountered in IVF patients. Treatment is usually based on inducing motility with pentoxyphylline (PXN) followed by ICSI. However, fertilization rate with this method is still lower compared with ICSI using motile sperm. One of the reasons for that is the immotile sperm inability to activate the oocyte Our research hypothesis is that better fertilization rate can be accomplished in these cases by combining PXN sperm activation with Ca ionophore oocyte activation.

Sex: All

Ages: 20 to 35 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Women up to 35 years of age
• immotile sperm
• At least 6 mature eggs

Exclusion criteria

• globozoospermia
• "Freeze all" cycles because of OHSS risk.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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0 participants in 2 patient groups

PXN only

Active Comparator group

Description:

Sperm activation with PXN before ICSI

Treatment:

Biological: PXN sperm treatment

PXN activation and oocyte activation

Experimental group

Description:

Sperm activation with PXN and oocyte activation

Treatment:

Biological: Sperm activation with PXN and oocyte activation