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FET-PET for Diagnosis and Monitoring in Patients With Low Grade Glioma

L

Ludwig Maximilian University of Munich

Status

Unknown

Conditions

Oligodendroglioma
Astrocytoma
Oligoastrocytoma

Study type

Observational

Funder types

Other

Identifiers

NCT01089244
GGN-CP4

Details and patient eligibility

About

The aim of the study is to compare the two imaging modalities perfusion weighted MR-imaging and FET-PET in their ability to provide an accurate histological evaluation of low grade glioma and to reveal focal abnormalities within a homogeneously appearing tumor. Additionally, therapeutic effects should be assessed during a time period of two years.

Enrollment

38 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • neuroradiologically suspected low grade glioma (Astrocytoma WHOI-II, Oligodendroglioma WHO II, Oligoastrocytoma WHO II)
  • histological verification will be obtained either by microsurgery or by stereotactic biopsy
  • patients older than 18 years
  • Karnofsky Performance Score >=70
  • pregnant or nursing female patients will not be included in this study

Exclusion criteria

  • patients in whom informed consent cannot be obtained due to organic brain syndrome or insufficient language skills
  • patients who cannot lie quiet for a time period of app. two hours during the FET-PEt scan
  • medical history of a metastatic brain disease
  • patients in whom an MRI scan cannot be performed due to claustrophobia metallic protheses or pacemakers etc.

Trial design

38 participants in 2 patient groups

Group A
Description:
Patients with a suspected WHO II low grade glioma, disease progression within 1 year
Group B
Description:
Patients with a suspected WHO II low grade glioma, progression free within 1 year

Trial contacts and locations

2

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Data sourced from clinicaltrials.gov

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