FET-PET for Diagnosis and Monitoring in Patients With Low Grade Glioma

Ludwig Maximilian University of Munich

Status: Unknown

Conditions: Oligodendroglioma; Astrocytoma; Oligoastrocytoma

Study type: Observational

Funder types: Other

Identifiers

NCT01089244

GGN-CP4

Details and patient eligibility

About

The aim of the study is to compare the two imaging modalities perfusion weighted MR-imaging and FET-PET in their ability to provide an accurate histological evaluation of low grade glioma and to reveal focal abnormalities within a homogeneously appearing tumor. Additionally, therapeutic effects should be assessed during a time period of two years.

Enrollment: 38 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• neuroradiologically suspected low grade glioma (Astrocytoma WHOI-II, Oligodendroglioma WHO II, Oligoastrocytoma WHO II)
• histological verification will be obtained either by microsurgery or by stereotactic biopsy
• patients older than 18 years
• Karnofsky Performance Score >=70
• pregnant or nursing female patients will not be included in this study

Exclusion criteria

• patients in whom informed consent cannot be obtained due to organic brain syndrome or insufficient language skills
• patients who cannot lie quiet for a time period of app. two hours during the FET-PEt scan
• medical history of a metastatic brain disease
• patients in whom an MRI scan cannot be performed due to claustrophobia metallic protheses or pacemakers etc.

Trial design

38 participants in 2 patient groups

Group A

Description:

Patients with a suspected WHO II low grade glioma, disease progression within 1 year

Group B

Description:

Patients with a suspected WHO II low grade glioma, progression free within 1 year