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Fetal and Neonatal Thyroid in Pregnancies With Severe Acute Respiratory Syndrome Coronavirus 2 ( SARS- COV2 ) COVID-19

O

OMER B ABDELBASIT

Status

Completed

Conditions

Hyperthyroidism
Hypothyroidism
Thyroid Dysfunction

Treatments

Drug: Thyroxine

Study type

Observational

Funder types

Other

Identifiers

NCT05385029
SecurityFH OABDELBASIT

Details and patient eligibility

About

The thyroid gland has been shown to be a common target for COVID 19 virus. Babies born to mothers positive for COVID 19 infections were noticed to have elevated thyroid stimulating hormone ( TSH ) levels on screening. Thyroid function tests were monitored in these babies to determine presence of temporary or permanent thyroid disorders following COVID 19 infections during pregnancy.

Full description

TSH estimation is carried out in all newborn babies in Saudi Arabia as a screening test for hypothyroidism. The first babies who were born to COVID 19 positive mothers were noticed to have significantly abnormal high TSH values. All the data and studies on the effect of COVID 19 on thyroid gland are from adult literature. Hence with these results of TSH in the the newborns we designed this observational study to monitor the thyroid functions in infants of COVID 19 positive mothers born in our hospital. The study confirmed presence of abnormal TSH and free thyroxine in these babies at birth and these babies were followed further after that for evidence of thyroid disorders.Results of thyroid functions in the babies who born in the same period of the study to mothers without COVID 19 infection were also recorded.

Enrollment

95 patients

Sex

Volunteers

No Healthy Volunteers

Inclusion criteria

  • All newborns

Exclusion criteria

  • Babies with congenital malformations

Trial design

95 participants in 2 patient groups

Thyroid functions in neonates born to COVID 19 positive mothers
Description:
thyroid hormone or antithyroid drugs
Treatment:
Drug: Thyroxine
Neonates born to mothers without COVID 19 infection
Description:
Thyroid drugs if indicated
Treatment:
Drug: Thyroxine

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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