Fetal Ano-genital Distance in 2D Ultrasound. (DAG)

Regional University Hospital Center (CHRU)

Status: Completed

Conditions: Prenatal Disorder; Urogenital Abnormalities; Sex Development Disorder

Study type: Observational

Funder types: Other

Identifiers

NCT03898440

DAG (29BRC18.0067)

Details and patient eligibility

About

The purpose of this study is to determine a threshold value of fetal anogenital distance in 2D ultrasound to differentiate male fetuses from female fetuses, starting 18 weeks of gestation and until the due date.

The study also evaluates the feasibility of the measure and its interobserver variability.

Full description

The anogenital distance of female newborns is shorter than that of male newborns.

Urogenital disorders, such as hypospadias and micro-penis, are associated with a shorter anogenital distance.

Anogenital distance is a good marker of fetal exposure to androgenic substances.

Prenatal anogenital distance ultrasound measure can help the diagnosis in case of doubt about fetal sexual phenotype or in case of urogenital disorder suspicion (hypospadias or micropenis).

Is the anogenital distance easy to make measure? Can this procedure be reproduced? What are the threshold values to determine fetal sex at each term of pregnancy?

Enrollment: 318 patients

Sex: Female

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• pregnant woman
• sonographic fetal follow up in Brest Hospital
• term>18 weeks of gestation

Exclusion criteria

• No datation between 11 weeks of gestation and 13 weeks of gestation and 6 days by crown-rump length measurement
• Minor
• no consent
• ultrasound performed by an operator without ultrasonography graduation