Fetal Magnetic Resonance Imaging: Z-score Reference Ranges for a Large Patient Population in Normal Neuroimaging Measurement (FMZSCORE)

Guangzhou Women and Children's Medical Center

Status: Invitation-only

Conditions: Fetal Growth Retardation; Fetal Neurodevelopmental Disorder

Study type: Observational

Funder types: Other

Identifiers

NCT07004283

2025282B00

Details and patient eligibility

About

This study aims to establish the z score reference ranges of fetal head circumference and other measurement of fetal measurements including biparietal diameter, fronto-occipital diameter, length of the corpus callosum, lateral ventricle, transverse cerebellar diameter, height of the vermis, anteroposterior diameter of the vermis，height and width of normal fetuses from 18 to 40 weeks' gestation.

Method-A cohort-based study was conducted on low-risk singleton pregnancies with healthy fetuses. The measurement was performed using simple 2-dimensional MRI on the typical fetal standard view. The reference ranges were constructed according to gestational age (GA), biparietal diameter (BPD), as independent variables based on the best-fit models, both mean and standard deviation (SD).

Enrollment: 800 estimated patients

Sex: Female

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• The pregnant women in Born in Guangzhou Cohort Study

Exclusion criteria

• The fetuses with prenatal diagnosis of congenital heart disease or other congenital diseases.

The fetuses who are high-risk neonates at the delivery.1) preterm infants; (2) infants with extremely low birth weight (ELBW) or who are small for gestational age (SGA);