Fetal Myocardial Performance Index in Diabetic Pregnancies

Kanuni Sultan Suleyman Training and Research Hospital

Status: Completed

Conditions: Gestational Diabetes; Myocardial Dysfunction

Treatments: Other: myocardial performance index

Study type: Observational

Funder types: Other

Identifiers

NCT03925064

2018.7.06

Details and patient eligibility

About

The myocardial tissue is the most likely structure affected by hyperglycemia. The myocardial performance index (MPI) is a pulsed wave Doppler-derived index of global myocardial function. It is defined as the sum of the isovolumetric contraction time (ICT) and isovolumetric relaxation time (IRT) divided by the ejection time (ET) The fetal right heart contributes more to the cardiac output than the left heart; therefore, it is important to assess the right ventricular function. The investigators will measure right ventricular MPI in diabetic and normal pregnancies.

Full description

Gestational diabetes mellitus (GDM) is the most common metabolic disorder in pregnancy, with an overall prevalence of 3-7 % during pregnancy. The myocardial tissue is the most likely structure affected by hyperglycemia. The myocardial performance index (MPI) is a pulsed wave Doppler-derived index of global myocardial function. It is defined as the sum of the isovolumetric contraction time (ICT) and isovolumetric relaxation time (IRT) divided by the ejection time (ET) The fetal right heart contributes more to the cardiac output than the left heart; therefore, it is important to assess the right ventricular function. The investigators will measure right ventricular MPI in diabetic and normal pregnancies.

Enrollment: 130 patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 18-40 years old pregnant women

Exclusion criteria

• fetal cardiac anomalies
• multiple gestations

Trial design

130 participants in 2 patient groups

Diabetic pregnancies

Description:

Pregnant women with pregestational or gestational diabetes mellitus

Treatment:

Other: myocardial performance index

non-diabetic pregnancies

Description:

Pregnant women without pregestational or gestational diabetes mellitus

Treatment:

Other: myocardial performance index