Fetal Renal Artery Doppler in Patients With Preeclampsia

Assiut University

Status: Enrolling

Conditions: Preeclampsia

Treatments: Other: fetal ultrasound

Study type: Observational

Funder types: Other

Identifiers

NCT06395974

Fetal renal a./preeclampsia

Details and patient eligibility

About

Preeclampsia is a major devastating disorder affects 2:10% of pregnancies worldwide. preeclampsia may be associated with placental insufficiency which may cause fetal blood redistribution to essential organs like brain, heart, kidney.

Full description

Preeclampsia is a major devastating medical condition that affects pregnant women after 20 weeks of pregnancy. It affects 2:10% of pregnancies worldwide according to World Health Organisation with higher incidence in developing countries.

Vascular endothelial dysfunction due to abnormal placentation is believed to be the main cause of multi-organ failure and uteroplacental insufficiency that occur in preeclampsia leading to major adverse effects in both mother and fetus.

Placental insufficiency causes a redistribution of fetal blood to essential organs ; brain, heart and adrenal glands by decreasing their vascular resistance on expense of peripheral organs such as kidney which exhibit increased vascular resistance and impaired perfusion. This is in contrast to normal pregnancies near term in which renal vascular resistance falls and increased blood flow to the kidneys is observed. Doppler ultrasound examination of vasculature of selected organs such as kidneys may have a role in detection of hemodynamic rearrangements that occur in cases of placental insufficiency and preeclampsia.

Enrollment: 88 estimated patients

Sex: Female

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• a) Preeclampsia:

  • Women with preeclampsia >28 weeks of pregnancy.

  • Singleton pregnancy.

  • Women with intrauterine growth restriction and abnormal amniotic fluid volume to simulate real world data.

    b) Control:

  • Women with healthy pregnancy matched by closest gestational age.

Exclusion criteria

• ● Multiple pregnancy.

  • Known Congenital fetal malformations.
  • Women with other comorbidity such as ischemic heart disease, DM, Autoimmune disorders, kidney disease, neurological disorders, liver or haematological disorders.
  • Women unable to provide informed consent.
  • Women who refuse to participate

Trial design

88 participants in 2 patient groups

preeclampsia

Treatment:

Other: fetal ultrasound

control

Treatment:

Other: fetal ultrasound