Fetuin A Association in Periodontal Disease and Diabetes Mellitus

Fayoum University

Status: Completed

Conditions: Periodontitis, Adult

Treatments: Diagnostic Test: GCF levels of fetuin A and hsCRP evaluation

Study type: Observational

Funder types: Other

Identifiers

NCT06064786

REC-FDBSU/03082023-2/ER

Details and patient eligibility

About

Aim: The aim of the current study was to compare and correlate gingival crevicular fluid (GCF) fetuin-A levels and high sensitivity C-reactive protein (hs-CRP) levels in non-diabetic periodontitis patients and type 2 diabetic periodontitis patients with healthy subjects and revealing its possible role in diagnosis of periodontal disease.

Methodology: Forty-five periodontitis stage III patients categorized into 3 groups according to whether having type II diabetes mellitus or not were compared to systemically and periodontally healthy participants in this investigation. Clinical parameters for all groups were recorded. Assessment of GCF levels of fetuin A and hs-CRP were done to all enrolled participants utilizing an enzyme linked immune-sorbent assay (ELISA) kit. Receiver operating characteristic (ROC) curve was performed to reveal sensitivity, specificity, predictive value and diagnostic accuracy of the markers used.

Enrollment: 45 patients

Sex: All

Ages: 20 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• both gender periodontitis stage III

Exclusion criteria

1. Smoking,
2. Systemic diseases (except DM in group B),
3. Periodontitis patients having periodontal treatment recently (past 6 months),
4. Pregnancy, lactation, contraceptive pills,
5. Anti-inflammatory/ immunosuppressive drugs.

Trial design

45 participants in 3 patient groups

Group I

Description:

15 healthy patients with generalized periodontitis stage III.

Treatment:

Diagnostic Test: GCF levels of fetuin A and hsCRP evaluation

Group II

Description:

15 patients suffering from type 2 diabetes mellitus with generalized periodontitis stage III

Treatment:

Diagnostic Test: GCF levels of fetuin A and hsCRP evaluation

Group III

Description:

15 systemically healthy patients without periodontitis

Treatment:

Diagnostic Test: GCF levels of fetuin A and hsCRP evaluation