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Fetuin-A Phosphorylation Status in Insulin Resistance and Metabolic Syndrome

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Auburn University

Status

Completed

Conditions

Obesity
Metabolic Syndrome

Treatments

Other: Weight loss

Study type

Interventional

Funder types

Other

Identifiers

NCT03478046
07-210-MR0710

Details and patient eligibility

About

Fetuin-A has been identified as a novel physiological regulator of insulin action in vitro, in intact cells and in vivo in animals. Previous research has shown that circulating levels of fetuin-A were increased in animal models of insulin resistance and diabetes. Additionally, several human investigation studies demonstrate a correlation of fetuin-A levels with body mass index, insulin resistance, and a fatty liver. Recently, the investigators have elucidated the role of fetuin-A phosphorylation in the regulation of insulin action, demonstrating that phosphorylation is critical for the inhibitory activity of fetuin-A. The objectives of this study are twofold: (1) Quantitate phosphorylated fetuin-A levels in individuals with insulin resistance and metabolic syndrome, and (2) Investigate the effects of lifestyle modifications (acute or chronic exercise and dietary modifications) on fetuin-A phosphorylation and insulin sensitivity.

Full description

There are several objectives of this study: (1) Quantitate phosphorylated fetuin-A levels and the daily variation in these levels in individuals with insulin resistance and metabolic syndrome; (2) Investigate the short-term responses of fetuin-A phosphorylation and changes in insulin resistance that occur with a single session of aerobic exercise; (3) Characterize and compare the total and temporal changes in fetuin-A phosphorylation and insulin resistance that occur with an 8 to 10% weight loss induced by chronic exercise training and dietary modification, and; (4) Investigate the influence of weight loss on the short-term responses of fetuin-A phosphorylation and changes in insulin resistance that occur with a single session of aerobic exercise. Our hypothesis is that phosphofetuin-A levels are tightly correlated with insulin resistance and that lifestyle modifications will improve insulin sensitivity and decrease phosphorylated fetuin-A levels.

Enrollment

42 patients

Sex

Male

Ages

30 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • 30 to 65 years of age
  • obese (BMI > 30 kg⋅m2 or % fat > 30, and waist girth > 88 cm)
  • weight stable over the previous 6 months

Exclusion criteria

  • smoker
  • documented cardiovascular or metabolic disease
  • currently taking medication to alter lipid or glucose metabolism
  • practicing regular leisure physical activity over the previous 6 months
  • engaged in strenuous vocational activity over the previous 6 months
  • signs or symptoms of latent heart disease
  • conditions that would preclude treadmill walking

Trial design

Primary purpose

Basic Science

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

42 participants in 1 patient group

Obese individuals
Experimental group
Description:
Apparently healthy, weight-stable, obese and physically inactive male volunteers will be recruited. Intervention is an 8 to 10% weight loss induced by chronic exercise training and dietary modification
Treatment:
Other: Weight loss

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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