Fiber Longer Term Study on Energy Intake (FLiTS)

Wageningen University

Status: Completed

Conditions: Healthy

Treatments: Dietary Supplement: LM pectin (10%); Dietary Supplement: gelatin

Study type: Interventional

Funder types: Other

Identifiers

NCT01526759

NL38515.081.11

Details and patient eligibility

About

Dietary fibre seems to have a relevant role in body weight management. In an acute study the investigators found that high viscous-high gelling pectin increased feelings of satiety. The objective of this study is to study the effects of 2 weeks of supplementation of high gelling-high viscous fibre or a high gelling-high viscous non-fibre control on energy intake.

The investigators do this by measuring the difference in ad libitum energy intake after 15 days of pectin or 15 days of control supplements. The investigators will further measure differences in 24h feelings of satiety, fasting blood glucose and insulin, fermentation and composition of microbiota.

Enrollment: 35 patients

Sex: All

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age: 18-30 year
• BMI: 18.5-25 kg/m2
• Healthy: as judged by the participant
• H2 producer

Exclusion criteria

• Weight loss or weight gain of more than 5 kg during the last 2 months
• Using an energy restricted diet during the last 2 months
• Lack of appetite for any reason
• Restrained eater
• Smoking
• Heavy alcohol use: >5 drinks/day
• Reported stomach or bowel diseases or disorders (e.g. irritable bowel syndrome)
• Reported diabetes
• Reported thyroid disease or any other endocrine disorder
• Using medication other than birth control, paracetamol, aspirin, hey fever and asthma
• Antibiotic use <2 months before the study
• Reported intolerance, allergy, or not liking of the research foods
• Vegetarian
• Current dietary fibre supplementation
• Fasting glucose levels >5.8 mmol/l
• Experienced any problems with drawing blood in the past
• Thesis students or employees of the division of Human Nutrition
• Volunteers who participated in the ProVe study

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

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35 participants in 2 patient groups, including a placebo group

pectin

Experimental group

Description:

10 gram high gelling-high viscous fiber, added to a drink

Treatment:

Dietary Supplement: LM pectin (10%)

control

Placebo Comparator group

Description:

10g gelatin, added to a drink

Treatment:

Dietary Supplement: gelatin