Fibre and Appetite Regulation Trial (FART)

University of Toronto

Status

Completed

Conditions

Diabetes

Obesity

Treatments

Drug: Low fibre breakfast cereal (puffed rice/cornflakes)

Drug: High fibre cereal (All Bran/Bran Flakes)

Study type

Interventional

Funder types

Other

Identifiers

NCT00247455

CDA1323

Can Diabetes Assoc Grant 1323

CIHR Grant OOP-64648

Details and patient eligibility

About

High intake of cereal fibre has been shown to be associated with reduced weight gain and improved insulin sensitivity. We hypothesize these effects are due to the short chain fatty acids derived from the bacterial fermentation (breakdown) of fibre in the colon (large intestine). Insulin resistant subjects will be randomized to receive 2 servings of a low-fibre cereal (eg. puffed rice) or 2 servings of a high-fibre cereal (wheat bran cereal) per day for one year. The effects of the diets on body weight, appetite, abdominal fat, blood short chain fatty acids, glucose, insulin, lipids and hormones will be measured

Sex

All

Ages

18 to 60 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Non-diabetic male or non-pregnant females
aged 18-60
BMI<36
fasting insulin >40pmol/L (70%ile)

Exclusion criteria

intention to lose >5kg in weight
presence of diabetes (fasting glucose >6.9mmol/L)
use of diuretics, beta-blockers or weight reducing drugs
use of antibiotics in last 3 months and use of antibiotics more than once annually for the last 2 years
significant gastrointestinal, liver or kidney disease
use of lipid-lowering drug
major medical or surgical event in last 6 mo.
fibre intake >30g/d
inability to eat low or high fibre breakfast cereals
unwilling or unable to give consent or comply with protocol