Fibrinogen Concentrate and Placenta Acreta Spectrum

Bakirkoy Dr. Sadi Konuk Training and Research Hospital

Status: Completed

Conditions: Placenta Accreta; Obstetric Anesthesia Problems

Treatments: Procedure: the group without fibrinogen concentrate (GNF) , the group with fibrinogen concentrate (GF)

Study type: Interventional

Funder types: Other

Identifiers

NCT05938062

2023-02

Details and patient eligibility

About

The aim of this study is to evaluate the relationship between fibrinogen use and bleeding in patients who underwent cesarean section with a prediagnosis of PAS.

The key question(s) it aims to answer are:

[Does the use of fibrinogen concentrate reduce bleeding in PAS patients?] Patients who had a cesarean section with a pre-diagnosis of PAS were analyzed retrospectively. The choice of anesthesia applied to the patients and the relationship between the use of blood products and bleeding were evaluated.

Full description

Our study was designed as a retrospective randomized study. Patients aged 20-50 years and >34 weeks of gestation who accepted the birth with a cesarean section with a pre-diagnosis of PAS were evaluated retrospectively.

examined. were randomized into 2 groups, 53 patients in each group: group1: GNF : the group without fibrinogen concentrate

Group 2: GF: the group with fibrinogen concentrate

Enrollment: 146 patients

Sex: Female

Ages: 20 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 20-50 years PAS pre-diagnosed pregnant women
• >34 weeks of pregnancy
• Those with normal renal functions

Exclusion criteria

• Patients with renal insufficiency
• Those with <34 weeks of gestation
• Pregnant women with missing data

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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146 participants in 2 patient groups

grup 1: the group without fibrinogen concentrate (GNF)

Experimental group

Description:

grup 1: the group without fibrinogen concentrate (GNF)

Treatment:

Procedure: the group without fibrinogen concentrate (GNF) , the group with fibrinogen concentrate (GF)

Grup 2: the group with fibrinogen concentrate

Experimental group

Description:

Grup 2: the group with fibrinogen concentrate

Treatment:

Procedure: the group without fibrinogen concentrate (GNF) , the group with fibrinogen concentrate (GF)