FILIP: Fat Intake, Inflammation and LIPids

Göteborg University

Status: Completed

Conditions: Inflammation; Cardiometabolic Risk Factors; Microbiota

Treatments: Other: Butter; Other: Rapeseed oil; Other: Coconut oil

Study type: Interventional

Funder types: Other

Identifiers

NCT06640036

2024-03117-01

Details and patient eligibility

About

Low-grade inflammation is involved in the pathogenesis of type 2 diabetes and cardiovascular disease. Increasing evidence suggests that dietary intake may be involved in the inflammatory process. How nutritional composition of the diet affects the inflammatory response is however not well understood.

The aim of this project is to study if intake of three different fat sources induce different effects on inflammation markers, blood lipids, blood glucose and the microbiota.

Enrollment: 25 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age 18-60
• Willing to eat the study diet

Exclusion criteria

• malabsorption-related condition
• contraindications to consume a high fat diet
• intolerance to any foods used in the study (e.g. cow's milk, egg, gluten)
• established cardiovascular disease, diabetes or cancer
• current use of medication known to affect lipid metabolism (e.g. statins) or inflammation (e.g. NSAID, glucocorticoids).
• hemoglobin <100 g/L
• ongoing pregnancy or lactation

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

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25 participants in 6 patient groups

Sequence 1: Rapeseed oil, butter, coconut oil

Experimental group

Description:

Diets rich in rapeseed oil, butter or coconut oil given in blinded, preprepared meals

Treatment:

Other: Coconut oil

Other: Rapeseed oil

Other: Butter

Sequence 2: Rapeseed oil, coconut oil, butter

Experimental group

Description:

Diets rich in rapeseed oil, butter or coconut oil given in blinded, preprepared meals

Treatment:

Other: Coconut oil

Other: Rapeseed oil

Other: Butter

Sequence 3: Butter, coconut oil , rapeseed oil

Experimental group

Description:

Diets rich in rapeseed oil, butter or coconut oil given in blinded, preprepared meals

Treatment:

Other: Coconut oil

Other: Rapeseed oil

Other: Butter

Sequence 4: Butter, rapeseed oil, coconut oil

Experimental group

Description:

Diets rich in rapeseed oil, butter or coconut oil given in blinded, preprepared meals

Treatment:

Other: Coconut oil

Other: Rapeseed oil

Other: Butter

Sequence 5: Coconut oil, rapeseed oil, butter

Experimental group

Description:

Diets rich in rapeseed oil, butter or coconut oil given in blinded, preprepared meals

Treatment:

Other: Coconut oil

Other: Rapeseed oil

Other: Butter

Sequence 6: Coconut oil, butter, rapeseed oil

Experimental group

Description:

Diets rich in rapeseed oil, butter or coconut oil given in blinded, preprepared meals

Treatment:

Other: Coconut oil

Other: Rapeseed oil

Other: Butter